1. GPCR/G Protein
  2. Adenosine Receptor

MRS 1754 

Cat. No.: HY-14121
Handling Instructions

MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats.

For research use only. We do not sell to patients.

MRS 1754 Chemical Structure

MRS 1754 Chemical Structure

CAS No. : 264622-58-4

Size Price Stock
5 mg USD 140 Get quote
10 mg USD 190 Get quote
25 mg USD 390 Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats[1].

IC50 & Target

A2B Adenosine Receptor[1]

In Vitro

The most potent displacer of [3H]MRS 1754 binding is MRS 1754. The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM[1].

Solvent & Solubility
In Vitro: 

DMSO : 22.5 mg/mL (46.25 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0554 mL 10.2771 mL 20.5541 mL
5 mM 0.4111 mL 2.0554 mL 4.1108 mL
10 mM 0.2055 mL 1.0277 mL 2.0554 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.25 mg/mL (4.62 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.25 mg/mL (4.62 mM); Suspended solution; Need ultrasonic

References
Molecular Weight

486.52

Formula

C₂₆H₂₆N₆O₄

CAS No.

264622-58-4

SMILES

O=C(NC1=CC=C(C#N)C=C1)COC2=CC=C(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)C=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
MRS 1754
Cat. No.:
HY-14121
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MRS 1754

Cat. No.: HY-14121