1. GPCR/G Protein
  2. Adenosine Receptor
  3. ZM241385

ZM241385 

Cat. No.: HY-19532 Purity: 99.26%
COA Handling Instructions

ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM.

For research use only. We do not sell to patients.

ZM241385 Chemical Structure

ZM241385 Chemical Structure

CAS No. : 139180-30-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 396 In-stock
Estimated Time of Arrival: December 31
100 mg USD 616 In-stock
Estimated Time of Arrival: December 31
200 mg USD 880 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ZM241385 purchased from MCE. Usage Cited in: Ecotoxicol Environ Saf. 2022 Dec 12;249:114410.  [Abstract]

    ZM241385 (10 μM) significantly decreases the levels of E-cad, increases the N-cad, Vimentin, and α-SMA levels by inhibiting A2aR, in A549 cells.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3].

    IC50 & Target

    Ki: 1.4 nM (A2AR)[2]

    In Vitro

    ZM241385 (1 μM; 24-48 hours; PC12 cells) treatment reverses the phenomenon that A2AR agonist CGS21680 significantly upregulates A2AR mRNA and protein levels[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    RT-PCR[1]

    Cell Line: PC12 cells
    Concentration: 1 μM
    Incubation Time: 24 hours
    Result: Suppressed the increased A2AR mRNA levels engendered by CGS21680.

    Western Blot Analysis[1]

    Cell Line: PC12 cells
    Concentration: 1 μM
    Incubation Time: 48 hours
    Result: Decreased A2AR protein levels
    In Vivo

    ZM241385 (0.2 μg/mouse, 0.4 μg/mouse; intraperitoneal injection; every day; for 11 weeks; female C57BL/6 WT mice) treatment decreases tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female C57BL/6 WT mice received 4-nitroquinoline-N-oxide[4]
    Dosage: 0.2 μg/mouse, 0.4 μg/mouse
    Administration: Intraperitoneal injection; every day; for 11 weeks
    Result: Decreased tumor volume, activates CD8+ T cells and reduces the frequency of splenic MDSC.
    Molecular Weight

    337.34

    Formula

    C16H15N7O2

    CAS No.
    SMILES

    OC1=CC=C(CCNC2=NC3=NC(C4=CC=CO4)=NN3C(N)=N2)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 30 mg/mL (88.93 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9644 mL 14.8218 mL 29.6437 mL
    5 mM 0.5929 mL 2.9644 mL 5.9287 mL
    10 mM 0.2964 mL 1.4822 mL 2.9644 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (6.17 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.08 mg/mL (6.17 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (6.17 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.26%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    ZM241385
    Cat. No.:
    HY-19532
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