Fagaceae

Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC₅₀ of 0.2 μM. Purpurogallin has antioxidant and anti-inflammatory effects.

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.

Arjunglucoside I, a natural compound, possesses antimicrobial activity with a MIC of 1.9 μg/mL.

Quercetin 3-O-robinobioside can be isolated from the leaves of Strychnos variabilis.

Roburin A is a dimeric ellagitannin and an Al^III ion chelator. Roburin A chelates Al³⁺ ions to form coordination compounds. Roburin A helps plants defend against toxic Al³⁺ ions released in acidic soils.

3,5-Di-O-galloylshikimic acid is a naturally derived phenolic acid compound with potential antiviral and hepatoprotective activities. 3,5-Di-O-galloylshikimic acid inhibits HIV replication, inactivates HIV viral particles and blocks virus-cell interactions. 3,5-Di-O-galloylshikimic acid has the potential to bind simultaneously to SARS-CoV-2 main protease (Mpro) and human ACE2 receptor. 3,5-Di-O-galloylshikimic acid can be used in studies related to coronavirus disease 2019 (COVID-19), acquired immunodeficiency syndrome (AIDS) and acute liver injury.

Bartogenic acid is an orally active NF-κB inhibitor, found in Barringtonia racemosa fruits. Bartogenic acid increases catalase, superoxide dismutase (SOD), and glutathione levels. Bartogenic acid inhibits lipid peroxidation and suppresses inflammation markers. Bartogenic acid can be used for the research of ovarian cancer, skin cancer, and inflammatory conditions.

(+)-Catechin 3-O-β-D-glucopyranoside (Compound 13) is an anti-allergic agent found in Edulis Superba. (+)-Catechin 3-O-β-D-glucopyranoside can be used for the research of inflammation and immunology.

Quercus infectoria extract is an extract from the fruit of the oak tree (Quercus infectoria) known for its powerful astringent, anti-inflammatory, and antioxidant properties. The active ingredients in Quercus infectoria extract include tannins (such as ellagic acid and gallic acid), flavonoids, and catechins.

6"-O-Feruloylphlorizin (Compound 3), a derivative of Phlorizin (HY-N0143), is isolated from the leaves of Lithocarpus glaber.

Quercetin 3'-methoxy-3-O-α-L-arabinofuranoside is a weak inhibitor of α-glucosidase, which can found in the leaves and twigs of Fagus hayatae.

1,7-Di-O-Galloyl-D-sedoheptulose is a phenolic acid that can be found in pomegranate arils.

Balanophonin B is a selective inhibitor (IC₅₀=1.46 μg/mL) that targets the lipopolysaccharide (LPS)-induced nitric oxide (NO) production pathway and can be isolated from Lithocarpus pachylepis. Balanophonin B inhibits the production of NO in LPS-stimulated RAW264.7 macrophages and exerts anti-inflammatory activity to reduce the inflammatory response. Balanophonin B can be used for anti-inflammatory drug development and biological activity research of natural lignan compounds.

Cycloheptenimine is a 8-Azabicyclo[5.1.0]octane found in Quercus Alba.

Ethyl brevifolincarboxylate (compound 3) can be isolated from Quercus wutaishanica seeds.

3, 4-seco-4 (23),20(29) -Lupadiene-3,28-dioic acid (Compound 5) is a triterpenoid compound. 3, 4-seco-4 (23),20(29) -Lupadiene-3,28-dioic acid has a strong inhibitory effect on the production of superoxide anions, and the inhibitory rate is 86.9±2.8% at 1 μM .

Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside is a acylated keampferol glucoside. Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside can be isolated from the leaves of O. dentata, acts as a repellent against a fouling organism, the blue mussel M. edulis.

Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside is a flavonoid compound that can be isolated from Quercus dentata. Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside suppresses the superoxide generation induced by arachidonic acid.