95753-52-9
Chemical Structure
3,5-Di-O-galloylshikimic acid
- CAS No.: 95753-52-9
- Formula:C21H18O13
- Molecular Weight:478.36
IUPAC Name: (3R,4S,5R)-4-hydroxy-3,5-bis((3,4,5-trihydroxybenzoyl)oxy)cyclohex-1-ene-1-carboxylic acid
InChIKey: GASRJYBPBZZTBO-IIDMSEBBSA-N
SMILES: O(C(=O)C1=CC(O)=C(O)C(O)=C1)[C@H]2[C@H](O)[C@H](OC(=O)C3=CC(O)=C(O)C(O)=C3)C=C(C(O)=O)C2
Biological Activity: 3,5-Di-O-galloylshikimic acid is a naturally derived phenolic acid compound with potential antiviral and hepatoprotective activities. 3,5-Di-O-galloylshikimic acid inhibits HIV replication, inactivates HIV viral particles and blocks virus-cell interactions. 3,5-Di-O-galloylshikimic acid has the potential to bind simultaneously to SARS-CoV-2 main protease (Mpro) and human ACE2 receptor. 3,5-Di-O-galloylshikimic acid can be used in studies related to coronavirus disease 2019 (COVID-19), acquired immunodeficiency syndrome (AIDS) and acute liver injury[1][2][3][4].
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3,5-Di-O-galloylshikimic acid | 3,5-Di-O-galloylshikimic acid is a naturally derived phenolic acid compound with potential antiviral and hepatoprotective activities. 3,5-Di-O-galloylshikimic acid inhibits HIV replication, inactivates HIV viral particles and blocks virus-cell interactions. 3,5-Di-O-galloylshikimic acid has the potential to bind simultaneously to SARS-CoV-2 main protease (Mpro) and human ACE2 receptor. 3,5-Di-O-galloylshikimic acid can be used in studies related to coronavirus disease 2019 (COVID-19), acquired immunodeficiency syndrome (AIDS) and acute liver injury. | |||||||||||||||||||||
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- [1]. Sharma P. Natural derivatives with dual binding potential against SARS-CoV-2 main protease and human ACE2 possess low oral bioavailability: a brief computational analysis. Journal of Biomolecular Structure and Dynamics, 2020.
- [2]. Nonaka G, et al. Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells. Journal of natural products. 1990;53(3):587-95. [Content Brief]
- [3]. Camarena-Rangel N G, et al. Identification of metabolites present in Opuntia callus and study of their antioxidant, anti-inflammatory and anti-adipogenic properties. Plant Cell, Tissue and Organ Culture, 2020, 143: 31-43.
- [4]. Hernández-Martínez J G, et al. The hepatoprotective effect of Opuntia callus metabolites on acute CCl4-induced intoxication in Wistar rats. SSRN, 2026.
Keywords
