24312-00-3
Chemical Structure
Castalagin
- CAS No.: 24312-00-3
- Formula:C41H26O26
- Molecular Weight:934.63
InChIKey: UDYKDZHZAKSYCO-CIBWSTISSA-N
SMILES: O=C(O[C@]1([C@@H]([C@@]([H])(OC(C2=C3C(O)=C(C(O)=C2C4=C(C(O)=C(C(C5=C(C(O)=C(C=C56)O)O)=C47)O)O)O)=O)[C@H]3O)OC7=O)[H])C8=CC(O)=C(C(O)=C8C9=C(C=C(C(O)=C9O)O)C(OC[C@]1(OC6=O)[H])=O)O
Biological Activity: Castalagin is an orally active natural product with multiple biological activities including antibacterial activity against bacteria and anti-leishmanial activity against Leishmania aethiopica. Castalagin exhibits inhibitory activity against PARP1 and DNA topoisomerase II, with an IC50 of 0.86 μM for bovine PARP1. Castalagin reduces poly (ADP-ribosyl) ation modification in cells. Castalagin binds to the cell envelope of Ruminococcus bromii, increases the ratio of CD8+/FOXP3+CD4+ T cells in the tumor microenvironment, and acts as a prebiotic to enhance the activity of anti-PD-1 therapy. Castalagin induces morphological changes in Leishmania aethiopica promastigotes and inhibits their proliferation. Castalagin inhibits PBP2a-mediated peptidoglycan layer stabilization, disrupts bacterial peptidoglycan assembly, and inhibits and disintegrates bacterial biofilms. Castalagin can be used in research related to diseases such as cancer, leishmaniasis, and bacterial infections[1][2][3][4].
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Castalagin | Castalagin is an orally active natural product with multiple biological activities including antibacterial activity against bacteria and anti-leishmanial activity against Leishmania aethiopica. Castalagin exhibits inhibitory activity against PARP1 and DNA topoisomerase II, with an IC50 of 0.86 μM for bovine PARP1. Castalagin reduces poly (ADP-ribosyl) ation modification in cells. Castalagin binds to the cell envelope of Ruminococcus bromii, increases the ratio of CD8+/FOXP3+CD4+ T cells in the tumor microenvironment, and acts as a prebiotic to enhance the activity of anti-PD-1 therapy. Castalagin induces morphological changes in Leishmania aethiopica promastigotes and inhibits their proliferation. Castalagin inhibits PBP2a-mediated peptidoglycan layer stabilization, disrupts bacterial peptidoglycan assembly, and inhibits and disintegrates bacterial biofilms. Castalagin can be used in research related to diseases such as cancer, leishmaniasis, and bacterial infections. | |||||||||||||||||||||
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- [1]. Kamada Y, et al. Castalagin and vescalagin purified from leaves of Syzygium samarangense (Blume) Merrill & L.M. Perry: Dual inhibitory activity against PARP1 and DNA topoisomerase II. Fitoterapia. 2018 Sep;129:94-101. [Content Brief]
- [2]. Messaoudene M, et al. A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti-PD-1 Resistance through Effects on the Gut Microbiota. Cancer discovery. 2022 Apr 01;12(4):1070-1087. [Content Brief]
- [3]. Shuaibu MN, et al. Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro. Parasitology Research, 2008, 103:1333-1338.
- [4]. Araújo AR, et al. Vescalagin and Castalagin Present Bactericidal Activity toward Methicillin-Resistant Bacteria. ACS biomaterials science & engineering. 2021 Mar 08;7(3):1022-1030. [Content Brief]
Keywords
