569-77-7
569-77-7
Chemical Structure
Purpurogallin
- CAS No.: 569-77-7
- Formula:C11H8O5
- Molecular Weight:220.18
IUPAC Name: 2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one
InChIKey: WDGFFVCWBZVLCE-UHFFFAOYSA-N
SMILES: O=C1C(O)=CC=CC2=CC(O)=C(O)C(O)=C21
Biological Activity: Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 μM. Purpurogallin has antioxidant and anti-inflammatory effects[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Purpurogallin | 98.06% | Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 μM. Purpurogallin has antioxidant and anti-inflammatory effects. | ||||||||||||||||||||
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Purpurogallin (Standard) | ≥98% | Purpurogallin (Standard) is the analytical standard of Purpurogallin. This product is intended for research and analytical applications. Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 μM. Purpurogallin has antioxidant and anti-inflammatory effects. | ||||||||||||||||||||
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Anthrarobin | Anthrarobin is an antipsoriatic agent with antibacterial and oxidative potential. | |||||||||||||||||||||
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1,3,5-Trihydroxyxanthone | 99.20% | 1,3,5-Trihydroxyxanthone is a Xanthones product that can be isolated from the herbs of Calophyllum inophyllum L.. | ||||||||||||||||||||
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SHP2-IN-5 | 98.58% | SHP2-IN-5 (compound 1) is an inhibitor of SHP2 (IC50: 97 nM). SHP2 is a non-receptor protein tyrosine phosphatase associated with cell growth and proliferation. SHP2-IN-5 has the potential to inhibit cancer and SHP2-related human diseases. | ||||||||||||||||||||
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1,6,7-Trihydroxyxanthone | 1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16. | |||||||||||||||||||||
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Purpurogallin carboxylic acid | Purpurogallin carboxylic acid, isolated from Macleaya microcarpa (Maxim.) Fedde, is an oxidation product of gallic acid in fermented tea. Purpurogallin carboxylic acid has anti-cancer activity. | |||||||||||||||||||||
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Urolithin M6 | 99.63% | Urolithin M6 is a polyhydroxy-rich metabolite with potential antioxidant activity. Urolithin M6 is produced by intestinal microbial metabolism and may act as an analog of tannic acid compounds. The production of Urolithin M6 in humans requires specific bacterial 3-dehydroxylase activity, which provides a new mechanism for its biotransformation. The metabolic profile of Urolithin M6 helps to stratify volunteers and further explore its potential role in health and disease. | ||||||||||||||||||||
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Urolithin M5 | 97.31% | Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC50 values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease. | ||||||||||||||||||||
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1,2,5-Trihydroxyxanthone | 1,2,5-Trihydroxyxanthone is a Xanthones product that can be isolated from the barks of Garcinia tetralata.. | |||||||||||||||||||||
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Mesuaxanthone B | Mesuaxanthone B (1,5,6-Trihydroxyxanthone) is a Sesquiterpenoids product that can be isolated from the fruits of Torilis japonica.. | |||||||||||||||||||||
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Norswertianin | 99.58% | Norswertianin, a xanthone compound, serves as a powerful anti-glioma compound. Norswertianin induces GBM cells differentiation through oxidative stress and Akt/mTOR dependent autophagy. | ||||||||||||||||||||
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References
- [1]. Park HY, et al. Purpurogallin exerts anti‑inflammatory effects in lipopolysaccharide‑stimulated BV2 microglial cells through the inactivation of the NF‑κB and MAPK signaling pathways. Int J Mol Med. 2013 Nov;32(5):1171-8. [Content Brief]
- [2]. Chang CZ, et al. Purpurogallin, a natural phenol, attenuates high-mobility group box 1 in subarachnoid hemorrhage induced vasospasm in a rat model. Int J Vasc Med. 2014;2014:254270. [Content Brief]
- [3]. Honda S, et al. Conversion to purpurogallin, a key step in the mechanism of the potent xanthine oxidase inhibitory activity of pyrogallol. Free Radic Biol Med. 2017 May;106:228-235. [Content Brief]
