2. Apoptosis
  3. Apoptosis
  4. 1,6,7-Trihydroxyxanthone

1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16.

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1,6,7-Trihydroxyxanthone Chemical Structure

1,6,7-Trihydroxyxanthone Chemical Structure

CAS No. : 25577-04-2

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1,6,7-Trihydroxyxanthone Related Antibodies

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Description

1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].

In Vitro

1,6,7-Trihydroxyxanthone (0-10 µg/mL; 0-72 h) inhibits cell proliferation in HepG2, Bel7404 cells[1].
1,6,7-Trihydroxyxanthone (5 µg/mL; 72 h) induces cell apoptosis in HepG2 cells[1].
1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].
1,6,7-Trihydroxyxanthone induces MiR-218 up-regulation in HepG2, Bel7404 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,6,7-Trihydroxyxanthone Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HepG2, Bel7404 cells
Concentration: 0, 1.25, 2.5, 5, 10 µg/mL
Incubation Time: 0, 24, 48, 72 h
Result: Inhibited cell proliferation of HepG2 and Bel7404 in a time- and dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 5 μg/ml
Incubation Time: 72 h
Result: Induced cell apoptosis.

Western Blot Analysis[1]

Cell Line: HepG2, Bel7404 cells
Concentration:
Incubation Time:
Result: Suppressed Bmi-1 expressio and increased the expression of P14, P16 protein levels.
Molecular Weight

244.20

Formula

C13H8O5
CAS No.
SMILES

O=C1C2=C(OC3=C1C=C(O)C(O)=C3)C=CC=C2O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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1,6,7-Trihydroxyxanthone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,6,7-Trihydroxyxanthone25577-04-2ApoptosisapoptosisantiproliferativeBmi-1P14P16MiR-218HepG2Bel7404 cellsInhibitorinhibitorinhibit

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