19086-75-0
19086-75-0
Chemical Structure
Castalin
- CAS No.: 19086-75-0
- Formula:C27H20O18
- Molecular Weight:632.44
InChIKey: PPUHUWSVCUJGTD-ONFJYYPGSA-N
SMILES: OC(C(O1)C2[C@@]([H])(O)C3=C(O)C(O)=C(O)C4=C3C(O2)=O)C(CO)OC(C5=CC(O)=C(O)C(O)=C5C6=C(O)C(O)=C(O)C4=C6C1=O)=O
Biological Activity: Castalin is a polyphenolic anticancer compound isolated and identified from the bark or nut shells of Castanea sativa Mill. Castalin induces DNA damage by increasing ROS to activate CHK1, while recruiting 53BP1/RIF1 and activating DNA-PKcs to initiate the NHEJ pathway for DNA repair. Castalin can be used in research related to cervical cancer and breast cancer[1][2].
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Castalin | Castalin is a polyphenolic anticancer compound isolated and identified from the bark or nut shells of Castanea sativa Mill. Castalin induces DNA damage by increasing ROS to activate CHK1, while recruiting 53BP1/RIF1 and activating DNA-PKcs to initiate the NHEJ pathway for DNA repair. Castalin can be used in research related to cervical cancer and breast cancer. | |||||||||||||||||||||
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References
- [1]. Lampire O, et al. Polyphenols isolated from the bark of castanea sativa Mill. chemical structures and auto-association in honour of professor G. H. Neil Towers 75th birthday. Phytochemistry 1998, 49, 623–631,
- [2]. D'Angelo M, et al. Castalin Induces ROS Production, Leading to DNA Damage and Increasing the Activity of CHK1 Inhibitor in Cancer Cell Lines. Antioxidants (Basel, Switzerland). 2025 Sep 08;14(9):1096.
