1. Anti-infection
    Membrane Transporter/Ion Channel
  2. HIV
    SGLT
  3. Trilobatin

Trilobatin 

Cat. No.: HY-N4100 Purity: 98.27%
Handling Instructions

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.

For research use only. We do not sell to patients.

Trilobatin Chemical Structure

Trilobatin Chemical Structure

CAS No. : 4192-90-9

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3].

IC50 & Target[2][3]

HIV-1

 

SGLT1/2

 

In Vitro

Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway[1].

Molecular Weight

436.41

Formula

C₂₁H₂₄O₁₀

CAS No.

4192-90-9

SMILES

OC(C=C1)=CC=C1CCC(C2=C(C=C(O[[email protected]@H]3O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]]3O)CO)C=C2O)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (572.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2914 mL 11.4571 mL 22.9142 mL
5 mM 0.4583 mL 2.2914 mL 4.5828 mL
10 mM 0.2291 mL 1.1457 mL 2.2914 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TrilobatinHIVSGLTHuman immunodeficiency virusSodium-dependent glucose cotransportersPC12AMPKNrf2Sirt3gp41envelopeentryAnti-tumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Trilobatin
Cat. No.:
HY-N4100
Quantity:
MCE Japan Authorized Agent: