Trilobatin
Based on 6 publication(s) in Google Scholar
Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.
For research use only. We do not sell to patients.
- Purity: 98.90%
- CAS No.: 4192-90-9
- Formula: C21H24O10
- Molecular Weight:436.41
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Trilobatin
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Customer Validation & Images
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Histological Imaging/Staining
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ELISA
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RT-PCR
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WB
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In Vivo Efficacy Study
Biological Activity
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HIV-1 |
SGLT1 |
SGLT2 |
Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4192-90-9
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Appearance Solid
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Molecular Weight 436.41
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Formula C21H24O10
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Color White to off-white
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SMILES
OC(C=C1)=CC=C1CCC(C2=C(C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2O)O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (6)
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Journal Impact Factor
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Most Recent
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Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 May 31:489:144992. PMID: 40466530 -
Phytomedicine
Protective effects of E Se tea extracts against alcoholic fatty liver disease induced by high fat/alcohol diet: In vivo biological evaluation and molecular docking study. [Abstract]2022 Jul:101:154113. PMID: 35490493 -
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
PLoS One
Trilobatin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice via the NF-κB pathway and alterations in gut microbiota. [Abstract]2024 Jun 24;19(6):e0305926. PMID: 38913606
Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]
Representative images of hematoxylin-eosin (HE)-stained colon tissue sections treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).
Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]
Expression levels of three inflammatory cytokines (TNF-α, IL-1β, and IL-6) in the sera of mice measured by ELISA treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).
Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]
Expression of mRNA levels of genes encoding tight junction proteins (ZO-1 and occludin) in colon tissue measured by qRT-PCR treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).
Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]
Protein levels of tight junction proteins (ZO-1 and occludin) in colon tissue measured by western blotting analysis treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).
Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]
Representative images of colon and colon length treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).
Solvent & Solubility
DMSO : 100 mg/mL (229.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 25 mg/mL (57.29 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Gao J, et al. Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway. Front Mol Neurosci. 2018 Jul 30;11:267. [Content Brief]
[2]. Yin S, et al. Trilobatin as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. FEBS Lett. 2018 Jul;592(13):2361-2377. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2914 mL | 11.4571 mL | 22.9142 mL | 57.2856 mL |
| 5 mM | 0.4583 mL | 2.2914 mL | 4.5828 mL | 11.4571 mL | |
| 10 mM | 0.2291 mL | 1.1457 mL | 2.2914 mL | 5.7286 mL | |
| 15 mM | 0.1528 mL | 0.7638 mL | 1.5276 mL | 3.8190 mL | |
| 20 mM | 0.1146 mL | 0.5729 mL | 1.1457 mL | 2.8643 mL | |
| 25 mM | 0.0917 mL | 0.4583 mL | 0.9166 mL | 2.2914 mL | |
| 30 mM | 0.0764 mL | 0.3819 mL | 0.7638 mL | 1.9095 mL | |
| 40 mM | 0.0573 mL | 0.2864 mL | 0.5729 mL | 1.4321 mL | |
| 50 mM | 0.0458 mL | 0.2291 mL | 0.4583 mL | 1.1457 mL | |
| 60 mM | 0.0382 mL | 0.1910 mL | 0.3819 mL | 0.9548 mL | |
| 80 mM | 0.0286 mL | 0.1432 mL | 0.2864 mL | 0.7161 mL | |
| 100 mM | 0.0229 mL | 0.1146 mL | 0.2291 mL | 0.5729 mL |
Trilobatin Related Classifications
HY-N4100 Related Classifications
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