2. Anti-infection
    Membrane Transporter/Ion Channel
  3. HIV
    SGLT
  4. Trilobatin

Trilobatin 

Cat. No.: HY-N4100 Purity: 99.00%
COA Handling Instructions

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.

For research use only. We do not sell to patients.

Trilobatin Chemical Structure

Trilobatin Chemical Structure

CAS No. : 4192-90-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 170 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 170 In-stock
Solid
5 mg USD 155 In-stock
10 mg USD 205 In-stock
25 mg USD 410 In-stock
50 mg USD 620 In-stock
100 mg USD 930 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Trilobatin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3].

IC50 & Target[2][3]

HIV-1

 

SGLT1

 

SGLT2

 

In Vitro

Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

436.41

Appearance

Solid

Formula

C21H24O10
CAS No.
SMILES

OC(C=C1)=CC=C1CCC(C2=C(C=C(O[[email protected]@H]3O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]]3O)CO)C=C2O)O)=O
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (286.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2914 mL 11.4571 mL 22.9142 mL
5 mM 0.4583 mL 2.2914 mL 4.5828 mL
10 mM 0.2291 mL 1.1457 mL 2.2914 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.00%

COA (247 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Trilobatin4192-90-9HIVSGLTHuman immunodeficiency virusSodium-dependent glucose cotransportersPC12AMPKNrf2Sirt3gp41envelopeentryAnti-tumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Trilobatin
Cat. No.:
HY-N4100
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email address *

Phone number

 

Department *

Organization name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.