1. Anti-infection
    Membrane Transporter/Ion Channel
  2. HIV
    SGLT
  3. Trilobatin

Trilobatin 

Cat. No.: HY-N4100
Handling Instructions

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.

For research use only. We do not sell to patients.

Trilobatin Chemical Structure

Trilobatin Chemical Structure

CAS No. : 4192-90-9

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Description

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3].

IC50 & Target[2][3]

HIV-1

 

SGLT1/2

 

In Vitro

Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway[1].

Molecular Weight

436.41

Formula

C₂₁H₂₄O₁₀

CAS No.

4192-90-9

SMILES

OC(C=C1)=CC=C1CCC(C2=C(C=C(O[[email protected]@H]3O[[email protected]@H]([[email protected]@H](O)[[email protected]](O)[[email protected]]3O)CO)C=C2O)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TrilobatinHIVSGLTHuman immunodeficiency virusSodium-dependent glucose cotransportersPC12AMPKNrf2Sirt3gp41envelopeentryAnti-tumorInhibitorinhibitorinhibit

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