Dihydrochalcones

Dihydrochalcones (10):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

Phloretin	60-82-2	99.67%
Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM, respectively.Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation.

HY-N0143

Phlorizin 60-81-1 99.82%

Phlorizin (Floridzin) is a non-selective SGLT inhibitor with K_is of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na⁺/K⁺-ATPase inhibitor.

Phlorizin	60-81-1	99.82%
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with K_is of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na⁺/K⁺-ATPase inhibitor.

Neohesperidin dihydrochalcone	20702-77-6	99.76%
Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

Trilobatin	4192-90-9	99.00%
Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.

Naringin Dihydrochalcone	18916-17-1	99.65%
Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

Loureirin B	119425-90-0	99.16%
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

Nothofagin	11023-94-2	≥98.0%
Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis). Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation.

HY-N10129

Uvaretin 58449-06-2

A mixture of uvaretin and isouvaretin (HY-N10130) exhibits significant antibacterial activity against B. subtilis (EC₅₀ 8.7 μM) and S. epidermidis (IC₅₀ 7.9 μM).
HY-N10130

Isouvaretin

A mixture of uvaretin (HY-N10129) and isouvaretin exhibits significant antibacterial activity against B. subtilis (EC₅₀ 8.7 μM) and S. epidermidis (IC₅₀ 7.9 μM).
HY-N1126

Trilobatin 2''-acetate 647853-82-5

Trilobatin 2''-acetate is a sweet Dihydrochalcone-glucoside that can be isolated from the leaves of Lithocarpus pachyphyllus.

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