2. Natural Products
  3. Flavonoids
  4. Dihydrochalcones

Dihydrochalcones

Dihydrochalcones (21):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0142
    Phloretin 60-82-2 99.92%
    Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill.，has anti-inflammatory activities. Phloridzin is a specific，competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM，respectively.Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation.
    Phloretin
  • HY-N0143
    Phlorizin 60-81-1 99.93%
    Phlorizin (Floridzin) is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities.
    Phlorizin
  • HY-N0154
    Neohesperidin dihydrochalcone 20702-77-6 99.94%
    Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.
    Neohesperidin dihydrochalcone
  • HY-N4100
    Trilobatin 4192-90-9 98.90%
    Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.
    Trilobatin
  • HY-N0119
    Naringin Dihydrochalcone 18916-17-1 99.53%
    Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.
    Naringin Dihydrochalcone
  • HY-W750903
    Dihydroxanthohumol 102448-00-0
    Dihydroxanthohumol is a chalcone found in Humulus lupulus L. Dihydroxanthohumol is a nitric oxide (NO) production inhibitor. Dihydroxanthohumol slightly suppresses LPS (HY-D1056)/IFN-γ-induced iNOS protein expression and NO production. Dihydroxanthohumol exhibits cytotoxicity at high concentrations.
    Dihydroxanthohumol
  • HY-N18313
    3′,8-Dimethoxy-4′,5,7-trihydroxyflavone 22132-85-0
    3′,8-Dimethoxy-4′,5,7-trihydroxyflavone (Compound 3) is a flavonoid compound that can be isolated from the aerial parts of Verbena littoralis.
    3′,8-Dimethoxy-4′,5,7-trihydroxyflavone
  • HY-N17610
    2',4'-Dihydroxydihydrochalcone 53596-71-7
    2',4'-Dihydroxydihydrochalcone exhibits cytotoxic activity against HT-29 colon adenocarcinoma cells (IC50 = 1.8 μM). 2',4'-Dihydroxydihydrochalcone may be used in research on cancers such as colon adenocarcinoma.
    2',4'-Dihydroxydihydrochalcone
  • HY-N1504
    Loureirin B 119425-90-0 99.96%
    Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
    Loureirin B
  • HY-113919
    Nothofagin 11023-94-2 ≥98.0%
    Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis). Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation.
    Nothofagin
  • HY-N16613
    Cyclobutanedichalcone 861706-38-9
    Cyclobutanedichalcone (Compound 7) is a natural product with a δ-Truxinic type structure. Cyclobutanedichalcone can be extracted from Agapanthus africanus.
    Cyclobutanedichalcone
  • HY-N16540
    4-Deoxyphlorizin 31018-48-1
    4-Deoxyphlorizin is a xyloglucan endotransglucosylase (XET) enhancer. 4-Deoxyphlorizin can enhance the XET-catalyzed transglycosylation reaction.
    4-Deoxyphlorizin
  • HY-N16556
    2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside 73519-16-1
    2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside (Compound 45) is a phenolic compound. 2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside can be isolated from Shorea roxburghii. 2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside can be used in the research of Cyclophosphamide (HY-17420)-induced peripheral neuropathy.
    2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside
  • HY-N0119R
    Naringin Dihydrochalcone (Standard) 18916-17-1
    Naringin Dihydrochalcone (Standard) is the analytical standard of Naringin Dihydrochalcone. This product is intended for research and analytical applications. Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.
    Naringin Dihydrochalcone (Standard)
  • HY-N10130
    Isouvaretin
    A mixture of uvaretin (HY-N10129) and isouvaretin exhibits significant antibacterial activity against B. subtilis (EC50 8.7 μM) and S. epidermidis (IC50 7.9 μM).
    Isouvaretin
  • HY-N12990
    Myrigalone A 34328-57-9
    Myrigalone A (MyA) is a plant ethylene biosynthesis inhibitor and natural herbicide. Myrigalone A possesses antioxidant, antifungal, and antimicrobial activities. Myrigalone A interferes with auxin homeostasis during seed germination. Myrigalone A delays seed germination, inhibits the formation of roots, hypocotyls, and root hairs, and causes developmental delay in specific organisms. Myrigalone A triggers the induction of detoxification programs, alters the metabolism of gibberellins, cis-(+)-12-oxophytodienoic acid, and jasmonic acid, disrupts the antioxidant system and oxidative signaling, and impairs the function of aquaporins and water uptake in imbibed seeds. Myrigalone A can be used in studies related to herbicides and plant growth regulators.
    Myrigalone A
  • HY-N4100R
    Trilobatin (Standard) 4192-90-9
    Trilobatin (Standard) is the analytical standard of Trilobatin. This product is intended for research and analytical applications. Trilobatin, a natural sweetener derived from?Lithocarpus polystachyus?Rehd, Trilobatin?is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.
    Trilobatin (Standard)
  • HY-N1504R
    Loureirin B (Standard) 119425-90-0
    Loureirin B (Standard) is the analytical standard of Loureirin B. This product is intended for research and analytical applications. Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
    Loureirin B (Standard)
  • HY-N0143R
    Phlorizin (Standard) 60-81-1
    Phlorizin (Floridzin) (Standard) is the analytical standard of Phlorizin. This product is intended for research and analytical applications. Phlorizin is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities.
    Phlorizin (Standard)
  • HY-N0154R
    Neohesperidin dihydrochalcone (Standard) 20702-77-6
    Neohesperidin dihydrochalcone (Standard) is the analytical standard of Neohesperidin dihydrochalcone. This product is intended for research and analytical applications. Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.
    Neohesperidin dihydrochalcone (Standard)