1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Nothofagin

Nothofagin 

Cat. No.: HY-113919
Handling Instructions

Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis). Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation.

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Nothofagin Chemical Structure

Nothofagin Chemical Structure

CAS No. : 11023-94-2

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Description

Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis)[1]. Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation[2].

In Vitro

Nothofagin pre-treatment (0.1, 1, 10 μM) decreases the level of histamine release in RBL-2H3 and RPMCs cells. The production of cytokines are downregulated bynothofagin pre-treatment Nothofagin (TNF-α: 1-10 μM; IL-4: 0.1-10 μM, IL-6: 1-10 μM)[1].
Pre-treatment of DNPHSA-stimulated RBL-2H3 with Nothofagin (10 μM) markedly suppresses the phosphorylation of Lyn, Syk, and Akt[1].
Nothofagin (30 μM; for 6 hours) results in inhibited formation of LPS-induced (100 ng/mL; 4 hours) paracellular gaps with the formation of dense F-actin rings in HUVECs[2].
Nothofagin suppresses IgE-mediated mast cell degranulation both in vitro and in vivo[1].

In Vivo

Nothofagin (1 mg/kg; orally; once a day; for 7 days) significantly increases the urinary volume of both normotensive (NTR) and spontaneously hypertensive rats (SHR)[3].

Animal Model: Male Wistar normotensive and spontaneously hypertensive rats (3-4 months old) [3]
Dosage: 1 mg/kg
Administration: Orally; once a day; for 7 days
Result: Significantly increased the urinary volume of both NTR and SHR.
Molecular Weight

436.41

Formula

C₂₁H₂₄O₁₀

CAS No.

11023-94-2

SMILES

OC1=C([[email protected]@H]([[email protected]@H]([[email protected]]2O)O)O[[email protected]@H]([[email protected]]2O)CO)C(O)=CC(O)=C1C(CCC(C=C3)=CC=C3O)=O

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Keywords:

NothofaginCalcium ChannelCa2+ channelsCa channelsdihydrochalconerooibosAspalathuslinearisNF-κBtranslocationcalciuminfluxantioxidantinflammatoryresponsessepticresponsevascularinflammationInhibitorinhibitorinhibit

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Nothofagin
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