XO/COX/LOX-IN-1 

XO/COX/LOX-IN-1 is a XO/COX/LOX inhibitor with an IC₅₀ of 3.2 μM against rat XO, 10.83 μM against 5-LOX, 12.67 μM against COX-1, and 8.31 μM against COX-2. XO/COX/LOX-IN-1 binds to the active sites of XO, 5-LOX, COX-1 and COX-2, thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation^[1].

XO/COX/LOX-IN-1 (Compound 7i) (10 min) inhibits rat liver XO activity by 62%^[1].
XO/COX/LOX-IN-1 (5-50 μM; 5 min) exhibits inhibitory effects on purified COX-1 (PDB ID: 2OYU), with an IC₅₀ value of 12.67 μM^[1].
XO/COX/LOX-IN-1 (5-50 μM; 5 min) inhibits purified COX-2 (PDB ID: 4COX) with an IC₅₀ of 8.31 μM^[1].
XO/COX/LOX-IN-1 (5-50 μM; 10 min) inhibits purified 5-LOX (PDB ID: 6N2W) with an IC₅₀ of 10.83 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

428.51

C₂₄H₂₀N₄O₂S

2831329-35-0

CC1=NC2=C(C=CC=C2OCC3=NN=C(COC4=CC=CC5=C4N=C(C=C5)C)S3)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zabiulla, et al. In-silico docking, synthesis, structure analysis, DFT calculations,energy frameworks, and pharmacological intervention of[1,3,4]-thiadiazoles analogous as XO inhibitor and on multiplemolecular inflammatory targets COX and LOX. Journal of Molecular Structure 1270 (2022) 133963.