XO/COX/LOX-IN-1
XO/COX/LOX-IN-1 is a XO/COX/LOX inhibitor with an IC50 of 3.2 μM against rat XO, 10.83 μM against 5-LOX, 12.67 μM against COX-1, and 8.31 μM against COX-2. XO/COX/LOX-IN-1 binds to the active sites of XO, 5-LOX, COX-1 and COX-2, thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation.
For research use only. We do not sell to patients.
- CAS No.: 2831329-35-0
- Formula: C24H20N4O2S
- Molecular Weight:428.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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COX-1 12.67 μM (IC50) |
COX-2 8.31 μM (IC50) |
5-LOX 10.83 μM (IC50) |
XO/COX/LOX-IN-1 (Compound 7i) (10 min) inhibits rat liver XO activity by 62%[1].
XO/COX/LOX-IN-1 (5-50 μM; 5 min) exhibits inhibitory effects on purified COX-1 (PDB ID: 2OYU), with an IC50 value of 12.67 μM[1].
XO/COX/LOX-IN-1 (5-50 μM; 5 min) inhibits purified COX-2 (PDB ID: 4COX) with an IC50 of 8.31 μM[1].
XO/COX/LOX-IN-1 (5-50 μM; 10 min) inhibits purified 5-LOX (PDB ID: 6N2W) with an IC50 of 10.83 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2831329-35-0
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Molecular Weight 428.51
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Formula C24H20N4O2S
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SMILES
CC1=NC2=C(C=CC=C2OCC3=NN=C(COC4=CC=CC5=C4N=C(C=C5)C)S3)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XO/COX/LOX-IN-1 Related Classifications
HY-151173 Related Classifications
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