2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase
  5. 12-LOX Isoform

12-LOX

 

12-LOX Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-12341
    ML355
    		Inhibitor 98.11%
    ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.
  • HY-W089800
    trans-2-Nonenal
    		Inhibitor 98.99%
    trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc..
  • HY-139055
    NCTT-956
    		Inhibitor
    NCTT-956 is a very effective platelet 12-lipoxygenase (12-LOX) activity-specific inhibitor.
  • HY-182696
    CGS 24891
    		Inhibitor
    CGS 24891 is an orally active 5-lipoxygenase (5-LO) inhibitor, with an IC50 value of 0.051 μM in guinea pigs and 0.11 μM in dogs. CGS 24891 inhibits the production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) from arachidonic acid. CGS 24891 weakly inhibits 12-lipoxygenase (12-LO) with an IC50 of 0.41 μM. CGS 24891 is applicable to research on inflammation and allergic reactions.
  • HY-175970
    MLS000099089
    		Inhibitor
    MLS000099089 is a 12/15-lipoxygenase (12/15-LOX) inhibitor with IC50 values of 3.4 μM and 10 μM for human and mice 12/15-LOX, respectively. MLS000099089 displays higher selectivity for 12/15-LOX over 5-LOX and COX-2. MLS000099089 can be used for the study of stroke.
  • HY-N16694
    6,7-Dehydroferruginol
    		Control
    6,7-Dehydroferruginol is a diterpenoid compound that can be isolated from the dichloromethane extract of Juniperus communis wood. At a concentration of 100 μg/mL, 6,7-Dehydroferruginol showed no inhibitory activity against 12(S)-LOX and did not inhibit the production of 12(S)-HETE.