1. Metabolic Enzyme/Protease
  2. 5-Lipoxygenase
  3. ML355

ML355 

Cat. No.: HY-12341 Purity: 98.28%
Handling Instructions

ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.

For research use only. We do not sell to patients.

ML355 Chemical Structure

ML355 Chemical Structure

CAS No. : 1532593-30-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 790 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE ML355

    ML355 purchased from MCE. Usage Cited in: Nat Med. 2018 Jan;24(1):73-83.

    The phosphorylated and total levels of p65, JNK, p38 and ERK in primary hepatocytes treated with ML355 (10 μM) under normoxia (Nor) or hypoxia (Hyp) conditions. For western blot analysis, GAPDH served as a loading control.
    • Biological Activity

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    • References

    • Customer Review

    Description

    ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.

    IC50 & Target

    IC50: 0.34 μM (12-LOX)[1]

    In Vitro

    ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells[1].

    In Vivo

    ML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls[3].

    Animal Model: C57BL/6 mice[3]
    Dosage: 1.88, 3.75, 7.5, 15, 30 mg/kg
    Administration: Oral gavage; 2 times per day for two days
    Result: The thrombus formation in mice was strongly inhibited by higher doses of ML355.
    Molecular Weight

    441.52

    Formula

    C₂₁H₁₉N₃O₄S₂

    CAS No.

    1532593-30-8

    SMILES

    O=S(NC1=NC2=CC=CC=C2S1)(C3=CC=C(NCC4=CC=CC(OC)=C4O)C=C3)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 42 mg/mL (95.13 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2649 mL 11.3245 mL 22.6490 mL
    5 mM 0.4530 mL 2.2649 mL 4.5298 mL
    10 mM 0.2265 mL 1.1325 mL 2.2649 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.28%

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    Keywords:

    ML355ML 355ML-3555-Lipoxygenase5-LOX5-LOInhibitorinhibitorinhibit

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    Product name:
    ML355
    Cat. No.:
    HY-12341
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