CGS 24891

Cat. No.: HY-182696: Data Sheet Handling Instructions
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CGS 24891 is an orally active 5-lipoxygenase (5-LO) inhibitor, with an IC₅₀ value of 0.051 μM in guinea pigs and 0.11 μM in dogs. CGS 24891 inhibits the production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B₄ (LTB₄) from arachidonic acid. CGS 24891 weakly inhibits 12-lipoxygenase (12-LO) with an IC₅₀ of 0.41 μM. CGS 24891 is applicable to research on inflammation and allergic reactions.

For research use only. We do not sell to patients.

CGS 24891 Chemical Structure

CAS No. : 134823-10-2

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

5-LO

0.051 (gui μM (IC₅₀)

5-LO

0.11 (dogs μM (IC₅₀)

12-LOX

0.41 μM (IC₅₀)

In Vitro

CGS 24891 potently inhibits 5-lipoxygenase activity in guinea pig polymorphonuclear leukocytes (PMNs) with an IC₅₀ value of 51 nM^[1].
CGS 24891 inhibits the activity of 5-lipoxygenase in canine whole blood, with an IC₅₀ of 0.11 μM^[1].
CGS 24891 inhibits 12-lipoxygenase activity in platelets with an IC₅₀ of 0.41 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGS 24891 (1 mg/kg; p.o.) exerts a duration of action of 15 h in dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

344.34

Formula

C₁₈H₁₇FN₂O₄

CAS No.

134823-10-2

SMILES

O=C(N(CC1=CC2=C(OC1)C=CC(OC3=CC=C(C=C3)F)=C2)O)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Satoh Y, et al. Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors. J Med Chem. 1993;36(23):3580-3594.

CGS 24891 Related Classifications

Inflammation/Immunology

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The dilution calculator equation

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGS 24891134823-10-2CGS24891CGS-24891LipoxygenaseLOX12-lipoxygenasethromboxane synthetasehumancyclooxygenase5-hydroxyeicosatetraenoic aciddogleukotriene B45-lipoxygenaseguinea pigarachidonic acidInhibitorinhibitorinhibit

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