2831329-35-0
Chemical Structure
XO/COX/LOX-IN-1
- CAS No.: 2831329-35-0
- Formula:C24H20N4O2S
- Molecular Weight:428.51
IUPAC Name: 9-(cyclopropylmethoxy)-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-5-(pyridin-4-ylmethoxy)-2H,6H-pyrano[3,2-b]xanthen-6-one
InChIKey: PRQCFOSPVNFQMV-UHFFFAOYSA-N
SMILES: CC1=NC2=C(C=CC=C2OCC3=NN=C(COC4=CC=CC5=C4N=C(C=C5)C)S3)C=C1
Biological Activity: XO/COX/LOX-IN-1 is a XO/COX/LOX inhibitor with an IC50 of 3.2 μM against rat XO, 10.83 μM against 5-LOX, 12.67 μM against COX-1, and 8.31 μM against COX-2. XO/COX/LOX-IN-1 binds to the active sites of XO, 5-LOX, COX-1 and COX-2, thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation[1].
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XO/COX/LOX-IN-1 | XO/COX/LOX-IN-1 is a XO/COX/LOX inhibitor with an IC50 of 3.2 μM against rat XO, 10.83 μM against 5-LOX, 12.67 μM against COX-1, and 8.31 μM against COX-2. XO/COX/LOX-IN-1 binds to the active sites of XO, 5-LOX, COX-1 and COX-2, thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation. | |||||||||||||||||||||
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