6-Formylpterin
Based on 1 Customer Validation
6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 712-30-1
- Formula: C7H5N5O2
- Molecular Weight:191.15
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
1.63 μM
Compound: 6-FP
|
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
|
[PMID: 37638616] |
6-Formylpterin (2 mM) generats intracellular ROS in HL-60 cells[1].
6-Formylpterin (0.5, 1, and 2 mM, 3 h) increases intracellular H2O2, which induces apoptosis in HL-60 cells and Jurkat cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60 cells, Jurkat cells
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Concentration:0.5, 1, and 2 mM
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Incubation Time:3 h
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Result:Induced apoptosis in HL-60 cells[1].
Inhibited Fas-mediated apoptosis in Jurkat cells in 0.5 mM[1].
Chemical Information
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CAS No. 712-30-1
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Appearance Solid
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Molecular Weight 191.15
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Formula C7H5N5O2
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Color Yellow to brown
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SMILES
O=CC1=CN=C2N=C(N)NC(C2=N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
H2O : 33.33 mg/mL (174.37 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)
1 M NaOH : 5 mg/mL (26.16 mM; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1 M NaOH / H2O | 1 mM | 5.2315 mL | 26.1575 mL | 52.3149 mL | 130.7873 mL |
| 5 mM | 1.0463 mL | 5.2315 mL | 10.4630 mL | 26.1575 mL | |
| 10 mM | 0.5231 mL | 2.6157 mL | 5.2315 mL | 13.0787 mL | |
| 15 mM | 0.3488 mL | 1.7438 mL | 3.4877 mL | 8.7192 mL | |
| 20 mM | 0.2616 mL | 1.3079 mL | 2.6157 mL | 6.5394 mL | |
| 25 mM | 0.2093 mL | 1.0463 mL | 2.0926 mL | 5.2315 mL | |
| H2O | 30 mM | 0.1744 mL | 0.8719 mL | 1.7438 mL | 4.3596 mL |
| 40 mM | 0.1308 mL | 0.6539 mL | 1.3079 mL | 3.2697 mL | |
| 50 mM | 0.1046 mL | 0.5231 mL | 1.0463 mL | 2.6157 mL | |
| 60 mM | 0.0872 mL | 0.4360 mL | 0.8719 mL | 2.1798 mL | |
| 80 mM | 0.0654 mL | 0.3270 mL | 0.6539 mL | 1.6348 mL | |
| 100 mM | 0.0523 mL | 0.2616 mL | 0.5231 mL | 1.3079 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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