Xanthine oxidase-IN-5
Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC50 value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model.
For research use only. We do not sell to patients.
- CAS No.: 2276711-87-4
- Formula: C18H16FN3O3
- Molecular Weight:341.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.70 μM (XO)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Potassium oxonate-induced hyperuricemic rat model[1]
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Dosage:20 mg/kg
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Administration:PO; single (measured serum uric acid after 0.5 - 8 hours)
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Result:Showed potent hypouricemic effects at an oral dose of 20 mg/kg in a rat hyperuricemia model induced by potassium oxonate.
Chemical Information
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CAS No. 2276711-87-4
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Molecular Weight 341.34
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Formula C18H16FN3O3
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SMILES
O=CC1=CC(F)=CC=C1OCC2=CN(CC3=CC=CC(OC)=C3)N=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Xanthine oxidase-IN-5 Related Classifications
HY-144456 Related Classifications
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