Phytic acid dodecasodium hydrate  (Synonyms: Inositol hexaphosphate dodecasodium hydrate)

Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium hydrate is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid dodecasodium hydrate inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects^[1][2][3][4].

Xanthine oxidase^[3]

Phytic acid dodecasodium hydrate (myo-Inositol) inhibits the formation of uric acid from xanthine with an IC₅₀ of about 30 mM. The generation of the superoxide is greatly affected by Phytic acid dodecasodium salt hydrate; the IC₅₀ is about 6 mM, indicating that the superoxide generating domain of XO is more sensitive to phytic acid^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solid

C₆H₈Na₁₂O₂₅P₆

123408-98-0

O=P(O[Na])(O[Na])O[C@H]1[C@H]([C@H]([C@H](OP(O[Na])(O[Na])=O)[C@@H](OP(O[Na])(O[Na])=O)[C@@H]1OP(O[Na])(O[Na])=O)OP(O[Na])(O[Na])=O)OP(O[Na])(O[Na])=O.[x].O

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Zhou JR, et al. Phytic acid in health and disease. Crit Rev Food Sci Nutr. 1995 Nov;35(6):495-508.  [Content Brief]

  [2]. Gupta RK, et al. Reduction of phytic acid and enhancement of bioavailable micronutrients in food grains. J Food Sci Technol. 2015 Feb;52(2):676-84.  [Content Brief]

  [3]. Muraoka S, et al. Inhibition of xanthine oxidase by phytic acid and its antioxidative action. Life Sci. 2004 Feb 13;74(13):1691-700.  [Content Brief]

  [4]. Lv Y, et al. Phytic acid attenuates inflammatory responses and the levels of NF-κB and p-ERK in MPTP-induced Parkinson's disease model of mice. Neurosci Lett. 2015 Jun 15;597:132-6.  [Content Brief]