1. GPCR/G Protein
  2. Adenosine Receptor
  3. Xanthine amine congener dihydrochloride

Xanthine amine congener dihydrochloride (Synonyms: XAC dihydrochloride)

Cat. No.: HY-110303
Handling Instructions

Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model.

For research use only. We do not sell to patients.

Xanthine amine congener dihydrochloride Chemical Structure

Xanthine amine congener dihydrochloride Chemical Structure

CAS No. : 1962928-23-9

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Description

Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model[1].

IC50 & Target

IC50: 1.8 nM (Adenosine A1 receptor)
IC50: 114 nM (Adenosine A2 receptor)[1]

In Vivo

Xanthine amine congener dihydrochloride is more potent as a convulsant than either caffeine or theophyllin in infusion studies at the dosage 39.8 mg/kg. XAC has no effects by administering the drug via an i.p. injection, the seizure threshold >1000 mg/kg[1].

Animal Model: Mice[1]
Dosage: 39.8 mg/kg
Administration: Infusion injection; single dose
Result: Acted as a convulsant agent than either caffeine or theophyllin.
Molecular Weight

501.41

Formula

C₂₁H₃₀Cl₂N₆O₄

CAS No.

1962928-23-9

SMILES

O=C1N(C(C2=C(N1CCC)N=C(C3=CC=C(C=C3)OCC(NCCN)=O)N2)=O)CCC.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Xanthine amine congenerXACAdenosine ReceptorP1 receptorconvulsantAdenosine receptorantagonistInhibitorinhibitorinhibit

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Xanthine amine congener dihydrochloride
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