1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Adenosine Receptor
    Phosphodiesterase (PDE)
  3. Diphylline

Diphylline (Synonyms: Diprophylline)

Cat. No.: HY-B0128 Purity: 99.07%
Handling Instructions

Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator drug and has the potential for chronic bronchitis and emphysema.

For research use only. We do not sell to patients.

Diphylline Chemical Structure

Diphylline Chemical Structure

CAS No. : 479-18-5

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10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 216 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Diphylline

    Diphylline purchased from MCE. Usage Cited in: Mol Ther Nucleic Acids. 2018 Nov 20;14:90-100.

    Expression levels of the apoptosis‑associated proteins including Bcl-2, Bax and active caspase‑3 are determined by western blot analysis with or without DPL.

    Diphylline purchased from MCE. Usage Cited in: Mol Ther Nucleic Acids. 2018 Nov 20;14:90-100.

    DPL downregulates the PI3K signaling pathway. The expression levels of key proteins associated with PI3K signaling, including AKT, p‑AKT, mTOR, p‑mTOR, p‑p70S6K and Cyclin D1, are detected by western blot analysis.
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    Description

    Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator drug and has the potential for chronic bronchitis and emphysema[1][2].

    In Vitro

    Dyphylline (trade names Dilor, Lufyllin), also known as diprophylline, is a xanthine derivative with bronchodilator and vasodilator effects. It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    254.24

    Formula

    C₁₀H₁₄N₄O₄

    CAS No.

    479-18-5

    SMILES

    O=C(N1C)N(C)C2=C(N(CC(O)CO)C=N2)C1=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (196.66 mM)

    H2O : 20 mg/mL (78.67 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9333 mL 19.6665 mL 39.3329 mL
    5 mM 0.7867 mL 3.9333 mL 7.8666 mL
    10 mM 0.3933 mL 1.9666 mL 3.9333 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3 mg/mL (11.80 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 3 mg/mL (11.80 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 3 mg/mL (11.80 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Keywords:

    DiphyllineDiprophyllineAdenosine ReceptorPhosphodiesterase (PDE)P1 receptorInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
    HY-B0128
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