Cat. No.: HY-W041301

(±)-Dihydroactinidiolide

Customer Review

Based on 1 Customer Validation

(±)-Dihydroactinidiolide is the dextrorotatory form of Dihydroactinidiolide (HY-107805). (±)-Dihydroactinidiolide has a strong, pleasant musky, tea-like and tobacco-like aroma and is mainly found in black tea, tobacco and fruits. (±)-Dihydroactinidiolide has antioxidant activity and can be derived from β-carotene.or light adaptation in Arabidopsis.

For research use only. We do not sell to patients.

Purity: 99.80%
CAS No.: 15356-74-8
Formula: C₁₁H₁₆O₂
Molecular Weight:180.25

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(±)-Dihydroactinidiolide Chemical Structure

CAS No.: 15356-74-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

(±)-Dihydroactinidiolide is one of the final products of β-carotene enzymatic oxidation degradation, and it can be generated from β-Ionone (HY-W015084) and β-Carotene 5,6-epoxide (HY-W750682)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 15356-74-8
Appearance Solid
Molecular Weight 180.25
Formula C₁₁H₁₆O₂
Color White to off-white
SMILES

O=C1OC2(C)C(C(C)(C)CCC2)=C1
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (554.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.5479 mL

27.7393 mL

55.4785 mL

5 mM

1.1096 mL

5.5479 mL

11.0957 mL

10 mM

0.5548 mL

2.7739 mL

5.5479 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (13.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (13.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (13.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (299 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kaneko H, et, al. The Aroma of Cigar Tobacco. Part I. Isolation of 2-Hydroxy-2,6,6-trimethylcyclohexylidene-1-acetic Acid Lactone (Dihydroactinidiolide) from Ether Extract of Cigar Leaves. Agricultural and Biological Chemistry. 1968 Jou; 32(11): 1337-40.

[2]. Bosser A, et, al. A Simple Way to (±)-Dihydroactinidiolide from β-Ionone Related to the Enzymic Co-oxidation of β-Carotene in Aqueous Solution. Biotechnology Progress. 1995 Jou; 11(6): 689-92.

[3]. Ferdosh S, et al. Extraction of Bioactive Compounds and Evaluation of Antioxidant Activity from Senna alata Linn Leaves using Subcritical Carbon Dioxide Soxhlet and Conventional Methods. The Natural Products Journal. 2025 Nov;15(8):E250724232281.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.5479 mL	27.7393 mL	55.4785 mL	138.6963 mL
	5 mM	1.1096 mL	5.5479 mL	11.0957 mL	27.7393 mL
	10 mM	0.5548 mL	2.7739 mL	5.5479 mL	13.8696 mL
	15 mM	0.3699 mL	1.8493 mL	3.6986 mL	9.2464 mL
	20 mM	0.2774 mL	1.3870 mL	2.7739 mL	6.9348 mL
	25 mM	0.2219 mL	1.1096 mL	2.2191 mL	5.5479 mL
	30 mM	0.1849 mL	0.9246 mL	1.8493 mL	4.6232 mL
	40 mM	0.1387 mL	0.6935 mL	1.3870 mL	3.4674 mL
	50 mM	0.1110 mL	0.5548 mL	1.1096 mL	2.7739 mL
	60 mM	0.0925 mL	0.4623 mL	0.9246 mL	2.3116 mL
	80 mM	0.0693 mL	0.3467 mL	0.6935 mL	1.7337 mL
	100 mM	0.0555 mL	0.2774 mL	0.5548 mL	1.3870 mL

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(±)-Dihydroactinidiolide

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Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

(±)-Dihydroactinidiolide Related Classifications

HY-W041301 Related Classifications