Nicotiana tabacum L.

Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases.

Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 μM).

Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities.

(+)-cis-Abienol (Compound Z-abienol), a diterpenoid, can be isolated from leaves of tobacco. (+)-cis-Abienol inhibits hyphal growth of P. nicotianae.

(1′S,2′S)-Nicotine-1'-oxide is a nicotine derivative and also a non/weakly potent α3β4 neuronal nicotinic acetylcholine receptor (nAChR) ligand.

4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases.

Fructose-leucine (Fru-Leu) is an Amadori compound that can be found in tobacco and is a precursor of aroma formed during the early stages of the Maillard reaction.

Epicatechin-5-O-β-D-glucopyranoside (Compound 9) is a glucoside. Epicatechin-5-O-β-D-glucopyranoside forms via regioselective 5-O-β-D-glucosylation of epicatechin of quercetin 3-O-D-glucoside.

(±)-Dihydroactinidiolide is the dextrorotatory form of Dihydroactinidiolide (HY-107805). (±)-Dihydroactinidiolide has a strong, pleasant musky, tea-like and tobacco-like aroma and is mainly found in black tea, tobacco and fruits. (±)-Dihydroactinidiolide has antioxidant activity and can be derived from β-carotene.or light adaptation in Arabidopsis.

STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3.

Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a K_i of 3300 nM.

(E/Z)-Geranylacetone is an organic compound commonly used as an ingredient in fragrances and fragrances. It can be used in some products such as perfumes, soaps and cosmetics, and can bring a fresh aromatic smell. In addition, the compound is used in some foods and pharmaceuticals, for example in candy, chewing gum and herbal remedies.

4-Methyl-1-pentanol is a volatile aroma component of red wine, which is often used in the production and blending of wine. 4-Methyl-1-pentanol can also be used as an alcohol antagonist to antagonize the effects of ethanol and 1-butanol on cell-cell adhesion, and is used in the study of fetal alcohol syndrome.

4-Ethyloctanoic acid is a branched chain aliphatic carboxylic acid that can be found in blue cheeses, various cheese types, and lamb/mutton. 4-Ethyloctanoic acid is a fragrance ingredient.

Nicotianamine is an orally active ACE inhibitor with an IC₅₀ of 76 nM for rhACE2 and an IC₅₀ of 59 nM for rhACE. Nicotianamine is also a metal chelator with high affinity for ferrous ions and other divalent metal cations. Nicotianamine is isolated from soybean. Nicotianamine reduces systolic blood pressure in spontaneously hypertensive rats. Nicotianamine chelates iron and zinc, promotes iron transport, enhances iron bioavailability through stable Fe²⁺-NA complexes and intestinal Fe²⁺ uptake, and promotes phloem-to-sink Fe mobilization, long-distance transport of Zn to leaves and flowers, and pollen development. Nicotianamine is a biosynthetic precursor of plant phytosiderophores, reverses chlorosis, and rescues sterility in NA-free mutants. Nicotianamine is used in research on hypertension, chlorosis, and iron deficiency anemia.

β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer.

α-Cembrenediol is a potent inhibitor of EBV.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity.

N-​Caffeoylputrescine,​(E)​- is a caffeic acid amide found in the tobacco plants (Nicotiana tabacum L.).

Anabasine (Standard) is the analytical standard of Anabasine. This product is intended for research and analytical applications. Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC₅₀=0.7 μM).

Phytuberin is an Antifungal terpenoid and phytoalexin. Phytuberin exists in potato tubers. Phytuberin exhibits antifungal activity against Phytophthora infestans. Phytuberin shows antifungal activity against both pathogenic and non-pathogenic fungi of potato. Phytuberin can be used in studies related to late blight and potato fungal infections.