529-84-0
Chemical Structure
4-Methylesculetin
- CAS No.: 529-84-0
- Formula:C10H8O4
- Molecular Weight:192.17
IUPAC Name: 6,7-dihydroxy-4-methyl-2H-chromen-2-one
InChIKey: KVOJTUXGYQVLAJ-UHFFFAOYSA-N
SMILES: O=C1C=C(C)C2=CC(O)=C(O)C=C2O1
Biological Activity: 4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases[1][2].
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4-Methylesculetin | 99.27% | 4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases. | ||||||||||||||||||||
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References
- [1]. Witaicenis A, et al. 4-methylesculetin, a coumarin derivative, ameliorates dextran sulfate sodium-induced intestinal inflammation. Chem Biol Interact. 2018 Jan 25;280:59-63. [Content Brief]
- [2]. Hemshekhar M, et al. Antiarthritic and antiinflammatory propensity of 4-methylesculetin, a coumarin derivative. Biochimie. 2013 Jun;95(6):1326-35. [Content Brief]
