6-Ethyl-7-hydroxy-4-methyl-2H-chromen-2-one
6-Ethyl-7-hydroxy-4-methyl-2H-chromen-2-one (Compound 32), a derivative of Coumarin (HY-N0709), acts as a Mcl-1 inhibitor with a Ki of 5.47 μM and an IC50 of 30.88 μM. 6-Ethyl-7-hydroxy-4-methyl-2H-chromen-2-one is applicable for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1484-73-7
- Formula: C12H12O3
- Molecular Weight:204.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Mcl-1 5.47 μM (Ki) |
Mcl-1 30.88 μM (IC50) |
6-Ethyl-7-hydroxy-4-methyl-2H-chromen-2-one (0.01-1000 μM; 30 min) inhibits the Mcl-1-BH3 peptide interaction with a Ki of 5.47 ± 0.09 μM and an IC50 of 30.88 ± 6.12 μM in a fluorescence polarization-based binding assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1484-73-7
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Molecular Weight 204.23
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Formula C12H12O3
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SMILES
O=C1OC=2C=C(O)C(=CC2C(=C1)C)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-Ethyl-7-hydroxy-4-methyl-2H-chromen-2-one Related Classifications
HY-W043574 Related Classifications
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