119-65-3
119-65-3
Chemical Structure
Isoquinoline
- CAS No.: 119-65-3
- Formula:C9H7N
- Molecular Weight:129.16
IUPAC Name: isoquinoline
InChIKey: AWJUIBRHMBBTKR-UHFFFAOYSA-N
SMILES: C12=C(C=NC=C2)C=CC=C1
Biological Activity: Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isoquinoline | 99.66% | Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities. | ||||||||||||||||||||
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Isoquinoline (Standard) | ≥98% | Isoquinoline (Standard) is the analytical standard of Isoquinoline. This product is intended for research and analytical applications. Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities. | ||||||||||||||||||||
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Isoquinoline-d7 | 99.33% | Isoquinoline-d7 is the deuterium labeled Isoquinoline. Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities. | ||||||||||||||||||||
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Isoquinoline-15N | Isoquinoline-15N is the 15N-labeled Isoquinoline (HY-W012732). Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities. | |||||||||||||||||||||
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2-Chloronaphthalene-d7 | 2-Chloronaphthalene-d7 is the deuterium labeled 2-Chloronaphthalene. | |||||||||||||||||||||
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7-Bromoisoquinoline | 99.91% | 7-Bromoisoquinoline is a brominated isoquinoline and synthetic precursor that constructs the isoquinoline functional group at the C17 position of target molecules. 7-Bromoisoquinoline serves as a key synthetic intermediate for the synthesis of cortistatin A-derived anti-angiogenic steroidal analogs (e.g., 7-tributylstannyl isoquinoline). 7-Bromoisoquinoline. | ||||||||||||||||||||
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8-Bromoisoquinoline | 99.51% | 8-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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6-Bromoisoquinoline | 98.18% | 6-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Phthalazine (Standard) | ≥98% | Phthalazine (Standard) is the analytical standard of Phthalazine. This product is intended for research and analytical applications. Phthalazine is a substrate for human aldehyde oxidase 1, which can lead to the production of ROS and subsequent enzyme inactivation. Phthalazine is a nitrogen-containing organic heterocyclic compound. Phthalazine exhibits antitumor activity in blood cancer, breast cancer, colon cancer, lung cancer and renal cancer. | ||||||||||||||||||||
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5-Hydroxyisoquinoline | 98.0% | 5-Hydroxyisoquinoline is a SARM1 inhibitor, IC50 = 2.6 μM, with axon-protective activity. 5-Hydroxyisoquinoline binds to and inhibits the NADase catalytic activity of the SARM1 protein TIR domain, reducing SARM1-mediated NAD+ depletion and cADPR production. 5-Hydroxyisoquinoline can be used in research on SARM1-related diseases; it can also serve as an intermediate for research related to organic synthesis. | ||||||||||||||||||||
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2-Bromonaphthalene-d7 | 99.88% | 2-Bromonaphthalene-d7 is the deuterium labeled 2-Bromonaphthalene. | ||||||||||||||||||||
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1-Iodonaphthalene-d7 | 1-Iodonaphthalene-d7 is the deuterium labeled 1-Iodonaphthalene (HY-W007608). | |||||||||||||||||||||
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5-Bromoisoquinoline | 97.55% | 5-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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5-Chloroisoquinoline | 5-Chloroisoquinoline (compound 42) is an inhibitor of SARM1 (Sterile alpha and toll/interleukin receptor (TIR) motif containing protein 1), an enzyme involved in axon degeneration that catalyzes multiple activities through a ternary complex mechanism. 5-Chloroisoquinoline can be used in the study of neurodegenerative diseases or axon degeneration. | |||||||||||||||||||||
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DSRM-3716 | 99.91% | DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection. | ||||||||||||||||||||
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3-Hydroxyquinoline-d6 | 3-Hydroxyquinoline-d6 (Quinolin-3-ol-d6) is the deuterium labeled 3-Hydroxyquinoline (HY-W008203). | |||||||||||||||||||||
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2-Naphthol-d7 | 98.53% | 2-Naphthol-d7 is the deuterium labeled 2-Naphthol. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2). | ||||||||||||||||||||
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1-Bromonaphthalene-d7 | 98.91% | 1-Bromonaphthalene-d7 is the deuterium labeled 1-Bromonaphthalene. | ||||||||||||||||||||
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1-Naphthol-d7 | 99.44% | 1-Naphthol-d7 (Furro ER-d7) is the deuterium labeled Naphthol (HY-Y1309). 1-Naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media. | ||||||||||||||||||||
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References
- [1]. Zhi-Xing Qing, et al. Anticancer and Reversing Multidrug Resistance Activities of Natural Isoquinoline Alkaloids and Their Structure-activity Relationship. Curr Med Chem [Content Brief]
- [2]. Iwasa K, et al. Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents. Bioorg Med Chem. 2001 Nov;9(11):2871-84. [Content Brief]
- [3]. Pesarico AP, et al. A novel isoquinoline compound abolishes chronic unpredictable mild stress-induced depressive-like behavior in mice. Behav Brain Res. 2016 Jul 1;307:73-83. [Content Brief]
- [4]. Chueh W H, et al. Protective effect of isoquinoline alkaloid berberine on spontaneous inflammation in the spleen, liver and kidney of non-obese diabetic mice through downregulating gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines[J]. Food Chemistry, 2012, 131(4): 1263-1271.
- [5]. Wright CW, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40. [Content Brief]
- [6]. Kim M, et al. Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway. Int Neurourol J. 2014 Sep;18(3):115-25. [Content Brief]
