β-Cembrenediol
Based on 1 Customer Validation
β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.16%
- CAS No.: 57605-81-9
- 화학식: C20H34O2
- 분자량:306.48
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
β-Cembrenediol (25, 50, 100, 200 µg/mL) shows inhibition on lettuce seedling stem length and root length in a dose-dependent manner[1].
β-Cembrenediol (0, 0.2, 0.5, 1, 5, 10 µM) reduces the migration and colony formation in a dose-dependent manner[2].
β-Cembrenediol (5, 10, 20 µM; 48 h) decreases the protein expression of TDO2, IDO1 in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3M cells
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Concentration:5, 10, 20 µM
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Incubation Time:48 h
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Result:Decreased the protein expression of TDO2, IDO1 in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male athymic nude mice (PC-3M PC cells)[2]
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Dosage:15 mg/kg
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Administration:P.o.; daily for 8 weeks
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Result:Significantly suppressed the development, extended the latency, and delayed the onset of the locoregional PC-3M cell tumor recurrence, reduced mice plasma total prostate-specific antigen and plasma kynurenine level.
Chemical Information
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CAS No. 57605-81-9
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Appearance Solid
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분자량 306.48
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화학식 C20H34O2
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Color White to off-white
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SMILES
O[C@]1(C)C[C@@H](O)/C=C(C)/CC/C=C(C)/CC[C@@H](C(C)C)/C=C/1
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ren X, et al. Isolation, Identification, and Autotoxicity Effect of Allelochemicals from Rhizosphere Soils of Flue-Cured Tobacco. J Agric Food Chem. 2015 Oct 21;63(41):8975-80. [Content Brief]
[2]. Mudhish EA, et al. The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase. Nutrients. 2022 Apr 4;14(7):1505. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Cembrenediol Related Classifications
HY-114319 Related Classifications
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