β-Cembrenediol
Based on 1 Customer Validation
β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.16%
- CAS No.: 57605-81-9
- Formule: C20H34O2
- Masse moléculaire:306.48
-
Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-15689
EpacadostatIDO1 Inhibitor -
HY-16724
IndoximodIDO Inhibitor -
HY-101111
PF-06840003IDO-1 Inhibitor -
HY-101560
LinrodostatIDO1 Inhibitor -
HY-18770B
NavoximodIDO Inhibitor -
HY-13983
IDO-IN-7 -
HY-N0707
(S)-IndoximodIDO Inhibitor -
HY-15689R
Epacadostat (Standard)IDO1 Inhibitor -
HY-151108
IDO1/TDO-IN-4IDO1/TDO Inhibitor -
HY-15683
IDO5LIDO Inhibitor -
HY-111540
LY-3381916IDO1 Inhibitor -
HY-N0430A
Coptisine SulfateIDO Inhibitor
Activité biologique
Description
In Vitro
β-Cembrenediol (25, 50, 100, 200 µg/mL) shows inhibition on lettuce seedling stem length and root length in a dose-dependent manner[1].
β-Cembrenediol (0, 0.2, 0.5, 1, 5, 10 µM) reduces the migration and colony formation in a dose-dependent manner[2].
β-Cembrenediol (5, 10, 20 µM; 48 h) decreases the protein expression of TDO2, IDO1 in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:PC-3M cells
-
Concentration:5, 10, 20 µM
-
Incubation Time:48 h
-
Result:Decreased the protein expression of TDO2, IDO1 in a dose-dependent manner.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male athymic nude mice (PC-3M PC cells)[2]
-
Dosage:15 mg/kg
-
Administration:P.o.; daily for 8 weeks
-
Result:Significantly suppressed the development, extended the latency, and delayed the onset of the locoregional PC-3M cell tumor recurrence, reduced mice plasma total prostate-specific antigen and plasma kynurenine level.
Chemical Information
-
CAS No. 57605-81-9
-
Appearance Solid
-
Masse moléculaire 306.48
-
Formule C20H34O2
-
Color White to off-white
-
SMILES
O[C@]1(C)C[C@@H](O)/C=C(C)/CC/C=C(C)/CC[C@@H](C(C)C)/C=C/1
-
Structure Classification
-
Initial Source
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
-
Fiche technique (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Ren X, et al. Isolation, Identification, and Autotoxicity Effect of Allelochemicals from Rhizosphere Soils of Flue-Cured Tobacco. J Agric Food Chem. 2015 Oct 21;63(41):8975-80. [Content Brief]
[2]. Mudhish EA, et al. The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase. Nutrients. 2022 Apr 4;14(7):1505. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Cembrenediol Related Classifications
HY-114319 Related Classifications
Powered by Bioz