1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Myosmine

Myosmine 

Cat. No.: HY-W001909
Handling Instructions

Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM.

For research use only. We do not sell to patients.

Myosmine Chemical Structure

Myosmine Chemical Structure

CAS No. : 532-12-7

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Description

Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM[1][2].

IC50 & Target

Ki: 3300 nM (a4b2 nAChR) and >10 µM (AT1)[1]

In Vitro

Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine[2].

In Vivo

Myosmine (0.001, 0.005, 0.5, and 50 micromol/kg; oral; in Wistar rats) causes a higher percentage of the radioactivity excreted in urine (86.2% and 88.9%) at the two lower doses (0.001 and 0.005 micromol/kg),as compared with the higher doses (0.5 and 50 micromol/kg), where only 77.8% and 75.4% of the dose is found in urine[2].

Molecular Weight

146.19

Formula

C₉H₁₀N₂

CAS No.

532-12-7

SMILES

C1(C2=NCCC2)=CN=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MyosminenAChRNicotinic acetylcholine receptorstobaccoalkaloida4b2nicotinicacetylcholinergicreceptorsInhibitorinhibitorinhibit

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Myosmine
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