Myosmine-d4
Based on 1 Customer Validation
Myosmine-d4 is the deuterium labeled Myosmine. Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM.
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 66148-17-2
- Formula: C9H6D4N2
- Molecular Weight:150.21
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 66148-17-2
-
Unlabeled Cas 532-12-7
-
Appearance Solid
-
Molecular Weight 150.21
-
Formula C9H6D4N2
-
Color Brown to reddish brown
-
SMILES
[2H]C1=C(C2=NCCC2)C([2H])=C([2H])C([2H])=N1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : ≥ 100 mg/mL (665.73 mM)
DMSO : 100 mg/mL (665.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. G Ferretti, er al. Binding of Nicotine and Homoazanicotine Analogues at Neuronal Nicotinic Acetylcholinergic (nACh) Receptors. Bioorg Med Chem Lett. 2003 Feb 24;13(4):733-5. [Content Brief]
[3]. Wolfgang Zwickenpflug, et al. Metabolism of Myosmine in Wistar Rats. Drug Metab Dispos. 2005 Nov;33(11):1648-56. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.6573 mL | 33.2867 mL | 66.5735 mL | 166.4337 mL |
| 5 mM | 1.3315 mL | 6.6573 mL | 13.3147 mL | 33.2867 mL | |
| 10 mM | 0.6657 mL | 3.3287 mL | 6.6573 mL | 16.6434 mL | |
| 15 mM | 0.4438 mL | 2.2191 mL | 4.4382 mL | 11.0956 mL | |
| 20 mM | 0.3329 mL | 1.6643 mL | 3.3287 mL | 8.3217 mL | |
| 25 mM | 0.2663 mL | 1.3315 mL | 2.6629 mL | 6.6573 mL | |
| 30 mM | 0.2219 mL | 1.1096 mL | 2.2191 mL | 5.5478 mL | |
| 40 mM | 0.1664 mL | 0.8322 mL | 1.6643 mL | 4.1608 mL | |
| 50 mM | 0.1331 mL | 0.6657 mL | 1.3315 mL | 3.3287 mL | |
| 60 mM | 0.1110 mL | 0.5548 mL | 1.1096 mL | 2.7739 mL | |
| 80 mM | 0.0832 mL | 0.4161 mL | 0.8322 mL | 2.0804 mL | |
| 100 mM | 0.0666 mL | 0.3329 mL | 0.6657 mL | 1.6643 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Powered by Bioz