2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. STAT3-IN-14

STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3.

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STAT3-IN-14 Chemical Structure

STAT3-IN-14 Chemical Structure

CAS No. : 123297-90-5

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STAT3-IN-14 Related Antibodies

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Description

STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3[1].

IC50 & Target

IC50: 0.42 μM (MDA-MB-231); 0.50 μM (MCF7); 0.13 μM (A549) [1]
In Vitro

STAT3-IN-14 (Compound 1) shows inhibitory activity against phosphor-STAT3.
STAT3-IN-14 (Compound 1) reduces the phosphorylation inhibitory activity against MDA-MB-231 cells (JAK/STAT pathway constitutively active) in does dependent manner, but no inhibitory activities against JAK kinases.
STAT3-IN-14 (Compound 1) has growth inhibitory activity with with IC50 values of 0.42 μM, 0.50 μM and 0.13 μM in MDA-MB-231, MCF7 and A549cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-14 Related Antibodies

Western Blot Analysis[1]

Cell Line: MCF7 cells; MDA-MB-231 cells
Concentration: 1 or 10 μM; 0.5, 1, 2, 4 μM
Incubation Time: 1 h; 2 h
Result: Completely inhibited STAT3 phosphorylation at 10 μM, and partial inhibition at 1 μM.
Reduced the phosphorylation of STAT3 in does dependent manner.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, MCF7 and A549 cells
Concentration: 0-30 μM
Incubation Time: 72 h
Result: Showed moderate to strong growth inhibitory activity among the three cancer cell lines.
Molecular Weight

258.23

Formula

C14H10O5
CAS No.
SMILES

O=C(C1=C2OC([C@@H](O)C)=C1)C3=C(C2=O)C=CC=C3O
Structure Classification
Initial Source
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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STAT3-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-14123297-90-5STATSTAT3 inhibitorJAK/STAT pathwayMDA-MB-231MCF7 A549Inhibitorinhibitorinhibit

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