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Lobetyolin 

Cat. No.: HY-N0327 Purity: 99.88%
Handling Instructions

Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect.

For research use only. We do not sell to patients.

Lobetyolin Chemical Structure

Lobetyolin Chemical Structure

CAS No. : 129277-38-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect.

In Vitro

Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. MUC5AC gene expression induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells is inhibited by pretreatment with Lobetyolin, lobetyol or methyl linoleate. Lobetyolin does not affect PMA-induced MUC5AC production from NCI-H292 cells. The amounts of mucin in the cells of Lobetyolin-treated cultures are 100±25%, 487±33%, 524±38%, 411±24%, and 402±45% for control, 10 ng/mL of PMA alone, PMA plus Lobetyolin 1 μM, PMA plus Lobetyolin 10 μM, and PMA plus Lobetyolin 100 μM, respectively[1].

References
Cell Assay
[1]

After 24 hours of serum deprivation, cells are pretreated with Lobetyolin, lobetyol or methyl linoleate (1, 10, and 100 µM), for 30 minutes and then treated with phorbol 12-myristate 13-acetate (PMA; 10 ng/mL) for 24 hours in serum-free RPMI 1640. After 24 hours, the spent media are collected to measure the secretion of MUC5AC protein and cells are lysed with buffer solution containing 20 mM Tris, 0.5% NP-40, 250 mM NaCl, 3 mM EDTA, 3 mM EGTA, and protease inhibitor cocktail and collected to measure the production of MUC5AC protein (in 24-well culture plate)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

396.43

Formula

C₂₀H₂₈O₈

CAS No.

129277-38-9

SMILES

O[[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]@H](CO)O[[email protected]]1OC(C(C#CC#C/C=C/C)O)/C=C/CCCO

Storage

-20°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.88%

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Product Name:
Lobetyolin
Cat. No.:
HY-N0327
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Lobetyolin

Cat. No.: HY-N0327