1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. Paeoniflorin

Paeoniflorin  (Synonyms: Peoniflorin)

Cat. No.: HY-N0293 Purity: 98.04%
COA Handling Instructions

Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity.

For research use only. We do not sell to patients.

Paeoniflorin Chemical Structure

Paeoniflorin Chemical Structure

CAS No. : 23180-57-6

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10 mM * 1 mL in DMSO USD 185 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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25 mg USD 50 In-stock
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100 mg USD 168 In-stock
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200 mg USD 300 In-stock
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Customer Review

Based on 14 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Paeoniflorin purchased from MCE. Usage Cited in: J Food Nutr Res. 2018, 6(1), 26-31.

    LPS-induced RAW264.7 cells are pre-treated with the MCR extract (50 and 100 μg/mL), Paeoniflorin (10 and 30 μM), and Oxypaeoniflorin (10 and 30 μM) for 4 h and then co-treated with LPS (1 μg/ml) for 18 h. The expression of iNOS protein using western blot.

    Paeoniflorin purchased from MCE. Usage Cited in: Oral Dis. 2019 Nov;25(8):1945-1953.  [Abstract]

    PF and BAI combination suppresses activation of the NF-κB signaling pathway in LPS-treated HOKs. Western blotting assay is performed to investigate expression of NF-κB inflammatory signaling proteins.

    Paeoniflorin purchased from MCE. Usage Cited in: Oral Dis. 2019 Nov;25(8):1945-1953.  [Abstract]

    The nuclear translocation of NF-κB p65 was visualized using a laser confocal scanning microscope imaging system. Nuclei detected with DAPI (blue). Cells expressing NF-κB p65 in the cytoplasm (green). NF-κB p65 expresses mostly in the nucleus, and a small amount expressed in the cytoplasm (green). Localization of NF-κB p65 in the cytoplasm (green)

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity[1][2][3].

    In Vitro

    Paeoniflorin (80 μg/mL; 4-24 h) treatment can induce Hsp40 and Hsp27 as well as Hsp70[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Western Blot Analysis[3]

    Cell Line: HeLa and IMR-32 cells
    Concentration: 80 μg/mL
    Incubation Time: 4, 8, 12, 16, and 24 hours
    Result: Promoted the phosphorylation of HSF1.
    In Vivo

    Paeoniflorin (intradermal injection; 25 and 100mg/kg; once daily; 20 days) shows favorable effects on experimental arthritis[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: SD rats with collagen induced arthritis[4]
    Dosage: 25 and 100mg/kg
    Administration: Intradermal injection; 25 and 100mg/kg; once daily; 20 days
    Result: Decreased arthritis score, relieved ankle and paw swelling, improved spleen istopathology, decreased the levels of IgA, IgM, IgG and anti-CII antibody.
    Clinical Trial
    Molecular Weight

    480.46

    Formula

    C23H28O11

    CAS No.
    SMILES
    Structure Classification
    Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (208.13 mM; Need ultrasonic)

    H2O : ≥ 100 mg/mL (208.13 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0813 mL 10.4067 mL 20.8134 mL
    5 mM 0.4163 mL 2.0813 mL 4.1627 mL
    10 mM 0.2081 mL 1.0407 mL 2.0813 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 98.04%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Paeoniflorin
    Cat. No.:
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