1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

Paeoniflorin (Synonyms: Peoniflorin)

Cat. No.: HY-N0293 Purity: >98.0%
Handling Instructions

Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.

For research use only. We do not sell to patients.

Paeoniflorin Chemical Structure

Paeoniflorin Chemical Structure

CAS No. : 23180-57-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 185 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 168 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg USD 300 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
500 mg   Get quote  
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    Paeoniflorin purchased from MCE. Usage Cited in: J Food Nutr Res. 2018, 6(1), 26-31.

    LPS-induced RAW264.7 cells are pre-treated with the MCR extract (50 and 100 μg/mL), Paeoniflorin (10 and 30 μM), and Oxypaeoniflorin (10 and 30 μM) for 4 h and then co-treated with LPS (1 μg/ml) for 18 h. The expression of iNOS protein using western blot.
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    Description

    Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall. Target: Others Paeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease(PD) [1]. Paeoniflorin, a compound found in white peony that inhibited the production of testosterone and promoted the activity of aromatase, which converts testosterone into estrogen [2]. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid-binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 microg/ mL (166.4 microM). To our knowledge, this is the first report on the induction of HSPs by herbal medicines [3].

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 27 mg/mL (56.20 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0813 mL 10.4067 mL 20.8134 mL
    5 mM 0.4163 mL 2.0813 mL 4.1627 mL
    10 mM 0.2081 mL 1.0407 mL 2.0813 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    480.46

    Formula

    C₂₃H₂₈O₁₁

    CAS No.

    23180-57-6

    SMILES

    O[[email protected]]1[[email protected]](O)[[email protected]@H](O)[[email protected]]([H])(O[[email protected]]2([[email protected]@]3(C)O[[email protected]]4([H])O[[email protected]@]5(C3)O)C[[email protected]]5([H])[[email protected]]24COC(C6=CC=CC=C6)=O)O[[email protected]@H]1CO

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: >98.0%

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    Product Name:
    Paeoniflorin
    Cat. No.:
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    Paeoniflorin

    Cat. No.: HY-N0293