2. Academic Validation
  3. Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment

Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment

  • Chem Biodivers. 2022 Aug;19(8):e202200295. doi: 10.1002/cbdv.202200295.
Xiao-Li Si 1 2,  Yan Wang 2 3,  Bo-Ni Song 4,  Yan Zhang 1,  Qing-Xia Yang 1,  Zhi Li 4,  Yan-Ping Luo 1,  Yong-Qiang Duan 2 5,  Xing-Ming Ma 1,  Yan-Ying Zhang 6
Affiliations

Affiliations

  • 1 Department of Immunology, School of Basic Medical Sciences, Lanzhou University, 199 West Donggang Road, Lanzhou, 730030, P. R. China.
  • 2 School of Basic Medical Sciences, Gansu University of Chinese Medicine, 35 East Dingxi Road, Lanzhou, 730030, P. R. China.
  • 3 School of Traditional Chinese Medicine, Ningxia Medical University, 1160 Victory Street, Yinchuan, 750004, P. R. China.
  • 4 School of Life Science and Engineering, Lanzhou University of Technology, 287 LanGongPing Road, Lanzhou, 730050, P. R. China.
  • 5 Key Laboratory of Dunhuang Medicine and Transformation of Ministry of Education, Gansu University of Chinese Medicine, 35 East Dingxi Road, Lanzhou, 730030, P. R. China.
  • 6 Scientific Research and Experimental Center, Gansu University of Chinese Medicine, 35 East Dingxi Road, Lanzhou, 730030, P. R. China.
PMID: 35841592 DOI: 10.1002/cbdv.202200295
Abstract

Chronic inflammation plays a positive role in the development and progression of colitis-associated colorectal Cancer (CAC). Medicinal Plants and their extracts with anti-inflammatory and immunoregulatory properties may be an effective treatment and prevention strategy for CAC. This research aimed to explore the potential chemoprevention of paeoniflorin (PF) for CAC by network pharmacology, molecular docking technology, and in vivo experiments. The results showed that interleukin-6 (IL-6) is a key target of PF against CAC. In the CAC mouse model, PF increased the survival rate of mice and decreased the number and size of colon tumors. Moreover, reduced histological score of colitis and expression of Ki-67 and PCNA were observed in PF-treated mice. In addition, the chemoprevention mechanisms of PF in CAC may be associated with suppression of the IL-6/STAT3 signaling pathway and the IL-17 level. This research provides experimental evidence of potential chemoprevention strategies for CAC treatment.

Keywords

IL-6/STAT3; colitis-associated colorectal cancer; molecular docking; network pharmacology; paeoniflorin.

Figures
Products