1. Apoptosis
  2. Apoptosis
  3. Atractylenolide III

Atractylenolide III (Synonyms: ICodonolactone; 8β-Hydroxyasterolide)

Cat. No.: HY-N0203 Purity: 99.91%
Handling Instructions

Atractylenolide III is a major component of Atractylodes rhizome can induce apoptosis of the lung carcinoma cells.

For research use only. We do not sell to patients.

Atractylenolide III Chemical Structure

Atractylenolide III Chemical Structure

CAS No. : 73030-71-4

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10 mM * 1 mL in DMSO USD 244 In-stock
Estimated Time of Arrival: December 31
10 mg USD 222 In-stock
Estimated Time of Arrival: December 31
50 mg USD 648 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Atractylenolide III is a major component of Atractylodes rhizome can induce apoptosis of the lung carcinoma cells. IC50 value: Target: Anticancer natural compound in vitro: ATL-III inhibited cell growth, increased lactate dehydrogenase release and modulated cell cycle on human lung carcinoma A549 cells. ALT-III induced the activation of caspase-3 and caspase-9 and cleavage of poly-(ADP)-ribose polymerase. ATL-III induced the release of cytochrome c, upregulation of bax expression, and translocation of apoptosis-inducing factor [1]. Atractylenolide II did not show cytoprotective effects, but oral administration of atractylenolide III dose-dependently prevented ethanol-induced PRGM cell death and cell membrane damage. The EC50 values were 0.27 and 0.34 mm, respectively [2]. Against adult D. pteronyssinus, atractylenolide III (LD50, 73.8 mg/m2) and atractylon (72.1 mg/m2) were eight times more active than Deet and 2.5-fold more toxic than dibutyl phthalate [3]. in vivo: In the in-vivo assay, atractylenolide III 10 mg/kg significantly reduced 70% ethanol-induced Wistar rat gastric ulcer. Atractylenolide III could inhibit matrix metalloproteinase (MMP)-2 and MMP-9 expression through upregulation of tissue inhibitors of metalloproteinase from the gastric ulcerated tissues [2].

Molecular Weight

248.32

Formula

C₁₅H₂₀O₃

CAS No.

73030-71-4

SMILES

O=C1C(C)=C(C[[email protected]@]23[H])[[email protected]@](C[[email protected]@]3(C)CCCC2=C)(O)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (201.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0271 mL 20.1353 mL 40.2706 mL
5 mM 0.8054 mL 4.0271 mL 8.0541 mL
10 mM 0.4027 mL 2.0135 mL 4.0271 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Atractylenolide IIIICodonolactone8β-HydroxyasterolideApoptosisInhibitorinhibitorinhibit

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Atractylenolide III
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