1. Apoptosis
  2. Apoptosis
  3. Curcumol

Curcumol (Synonyms: (-)-Curcumol)

Cat. No.: HY-N0104 Purity: 99.49%
Handling Instructions

Curcumol ((-)-Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers.

For research use only. We do not sell to patients.

Curcumol Chemical Structure

Curcumol Chemical Structure

CAS No. : 4871-97-0

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5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Curcumol purchased from MCE. Usage Cited in: Mol Med Rep. 2018 Jun;17(6):7513-7520.

    Curcumol alters the expression levels of genes in the EMT pathway. Western blot analysis of the expression of E cadherin protein. Western blot analysis of the expression of N cadherin protein.
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    Description

    Curcumol ((-)-Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers[1].

    In Vitro

    Curcumol ((-)-Curcumol) is the major component extracted from root of Rhizoma Curcumae. Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3[2]
    . Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway[3]
    . Curcumol suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt-dependent NF-κB signaling pathways[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    236.35

    Formula

    C₁₅H₂₄O₂

    CAS No.
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    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (423.10 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.2310 mL 21.1551 mL 42.3101 mL
    5 mM 0.8462 mL 4.2310 mL 8.4620 mL
    10 mM 0.4231 mL 2.1155 mL 4.2310 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.49%

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    Keywords:

    Curcumol(-)-CurcumolApoptosisbioactivesesquiterpenoidanticancerantimicrobialantifungalantiviralanti-inflammatorybreastInhibitorinhibitorinhibit

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    Product Name:
    Curcumol
    Cat. No.:
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