1. Anti-infection
  2. Virus Protease
  3. Glycyrrhizic acid

Glycyrrhizic acid (Synonyms: Glycyrrhizin)

Cat. No.: HY-N0184 Purity: >98.0%
Handling Instructions

Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

For research use only. We do not sell to patients.

Glycyrrhizic acid Chemical Structure

Glycyrrhizic acid Chemical Structure

CAS No. : 1405-86-3

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 84 In-stock
Estimated Time of Arrival: December 31
200 mg USD 120 In-stock
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Glycyrrhizic acid:

Top Publications Citing Use of Products

    Glycyrrhizic acid purchased from MCE. Usage Cited in: Cell Prolif. 2020 May 17;e12829.

    Protein levels of pro-caspase-1 + p10 + p12, GADMD, IL-1β, IL-18 and NLRP3 are detected by Western blotting. Glycyrrhizin inhibits pyroptosis in TNF-α-induced M1 macrophages.
    • Biological Activity

    • Protocol

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    • References

    • Customer Review

    Description

    Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

    In Vitro

    Glycyrrhizic acid shows a series of anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms, as a carrier material in drug delivery systems[1]. In intestinal NCI-H716 cells that secretes GLP-1, Glycyrrhizic acid promotes GLP-1 secretion with a marked elevation of calcium levels. Glycyrrhizic acid can enhance GLP-1 secretion through TGR5 activation[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), Glycyrrhizic acid increases the level of plasma GLP-1, which is blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5)[1]. Glycyrrhizic acid (Glycyrrhizic acid; 50 mg/kg, i.p.) significantly decreases the levels of TgAb, HMGB1, TNF-α, IL-6, IL-1β in mice[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    822.93

    Formula

    C₄₂H₆₂O₁₆

    CAS No.

    1405-86-3

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 900 mg/mL (1093.65 mM; Need ultrasonic and warming)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2152 mL 6.0759 mL 12.1517 mL
    5 mM 0.2430 mL 1.2152 mL 2.4303 mL
    10 mM 0.1215 mL 0.6076 mL 1.2152 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 10 mg/mL (12.15 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 10 mg/mL (12.15 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 10 mg/mL (12.15 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO  90% saline

      Solubility: 10 mg/mL (12.15 mM); Clear solution; Need ultrasonic and warming

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [3]

    Mice[3]
    NOD.H-2h4 mice are fed in the animal house until 4 weeks of age. A total of 24 male mice are then randomly separated into three different groups (n=8 per group). Mice in the control group are given sterile water without supplement. Mice in the iodine supplement (NaI) group are given 0.005% NaI in the drinking water. Mice in the NaI+Glycyrrhizic acid group are treated with 50 mg/kg Glycyrrhizic acid once daily for 4 weeks, administered via intraperitoneal injection after 8 weeks of iodine supplementation. Thyroid tissues are removed surgically under anesthesia, washed with cold saline, blotted on filter paper and weighed using an electronic balance. The thyroid gland tissues are then stored at -80°C until use[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    Keywords:

    Glycyrrhizic acidGlycyrrhizinVirus ProteaseInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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