1. Natural Products
  2. Disease Research Fields Plants Terpenoids
  3. Leguminosae Inflammation/Immunology Triterpenes
  4. Glycyrrhiza uralensis Fisch.
  5. Ammonium glycyrrhizinate

Ammonium glycyrrhizinate  (Synonyms: Monoammonium glycyrrhizinate; Glycyrrhizic acid ammonium salt; Ammonium glycyrrhizate)

Cat. No.: HY-76225 Purity: 98.31%
COA Handling Instructions

Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.

For research use only. We do not sell to patients.

Ammonium glycyrrhizinate Chemical Structure

Ammonium glycyrrhizinate Chemical Structure

CAS No. : 53956-04-0

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Solid + Solvent
10 mM * 1 mL in DMSO
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100 mg USD 80 In-stock
500 mg USD 240 In-stock
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Customer Review

Based on 23 publication(s) in Google Scholar

Other Forms of Ammonium glycyrrhizinate:

Top Publications Citing Use of Products

    Ammonium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2020 Jun;53(6):e12829.  [Abstract]

    Protein levels of pro-caspase-1 + p10 + p12, GADMD, IL-1β, IL-18 and NLRP3 are detected by Western blotting. Glycyrrhizin inhibits pyroptosis in TNF-α-induced M1 macrophages.
    • Biological Activity

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    • Customer Review

    Description

    Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities. In Vivo:The increase of the lung W/D weight ratios is significantly reduced by high and medium dose of MAG (10 and 30 mg/kg) administration. Pretreatment with MAG (10 and 30 mg/kg) efficiently reduces the production of TNF-α and IL-1β. MAG (10, 30 mg/kg) significantly decreases NF-κB p65 protein expression, compared with LPS. On the contrary, LPS significantly reduces IκB-α protein expression compared with the control group, whereas MAG (10 and 30 mg/kg) significantly increased I𝜅B-𝛼 expression, compared with the LPS group[1].
    Low- and high-dose MAG treatment significantly reduces the AST, ALT, TBIL, and TBA levels at 14 and 21 d time points when compared with that of the RIF and INH group, suggesting the protective effect of MAG on RIF- and INH-induced liver injury. MAG treatment groups elevate the hepatic GSH level at 7, 14, and 21 d time points and markedly reduce the MDA level at 14 and 21 d time points in RIF- and INH-treated rats, suggesting the protective effect of MAG in RIF- and INH induced liver injuries[2].

    Clinical Trial
    Molecular Weight

    839.96

    Formula

    C42H65NO16

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1[C@]([C@](CC2)(C)[C@@]3(C)C([C@]([C@@]4(C)CC3)([H])C[C@@](CC4)(C)C(O)=O)=C1)([H])[C@](CC5)(C)[C@]2([H])C([C@H]5O[C@@H](O[C@H](C(O)=O)[C@H]6O)[C@H](O[C@@H]([C@H](O)[C@@H](O)[C@@H]7O)O[C@@H]7C(O)=O)[C@H]6O)(C)C.N

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (119.05 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1905 mL 5.9527 mL 11.9053 mL
    5 mM 0.2381 mL 1.1905 mL 2.3811 mL
    10 mM 0.1191 mL 0.5953 mL 1.1905 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (2.98 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (2.98 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (2.98 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.31%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Ammonium glycyrrhizinate
    Cat. No.:
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