2. Neuronal Signaling Anti-infection
  3. Amyloid-β Influenza Virus
  4. Geniposide

Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

For research use only. We do not sell to patients.

CAS No. : 24512-63-8

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Customer Review

Based on 19 publication(s) in Google Scholar

Other Forms of Geniposide:

Geniposide Related Antibodies

Top Publications Citing Use of Products

    Geniposide purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2025 Sep 30:19:8805-8821.  [Abstract]

    Cell viability of RAW264.7 which were treated with Geniposide (0, 5, 10, 20, 50, 100, 200, 500 μM) for 24 h measured by CCK-8.

    Geniposide purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2025 Sep 30:19:8805-8821.  [Abstract]

    Immunofluorescent detection of the iNOS (M1 marker, Red fluorophores), Arg-1 (M2 marker, Red fluorophores), and DAPI (nucleus, Blue fluorophores) after treating with Gen (5, 10, 20μM).

    Geniposide purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2025 Sep 30:19:8805-8821.  [Abstract]

    RAW264.7 cells were pre-treated with GW9662 (5 µM) for 1 h and exposed to Geniposide (20 µM) for 24 h. Gene expressions of CD36 and ABCG1 were measured by RT-Qpcr.

    Geniposide purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2025 Sep 30:19:8805-8821.  [Abstract]

    RAW264.7 cells were treated with Geniposide (20 µM) for 0, 30, 60, 120, 180 min. Total and phosphorylated-PPARγ levels in nuclear and cytoplasm extracts were analyzed using Western Blot.

    Geniposide purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2025 Sep 30:19:8805-8821.  [Abstract]

    RAW264.7 cells were pre-treated with GW9662 (5 µM) for 1 h and exposed to Geniposide (20 µM) for 24 h. Total RNA was extracted and subjected to RT-qPCR for the assessments of Fizz-1, Ym-1 and Arg-1 levels.

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

    Cellular Effect
    Cell Line Type Value Description References
    Melanocyte EC50
    1.65 μM
    Compound: 197
    Upregulation of NE suppressed c-Kit expression in human epidermal melanocyte
    Upregulation of NE suppressed c-Kit expression in human epidermal melanocyte
    		[PMID: 38422702]
    RAW264.7 IC50
    > 100 μM
    Compound: 9
    Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method
    Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method
    		[PMID: 23305920]
    In Vitro

    Geniposide exhibits a variety of activities, such as on antithrombosis, anti-inflammation, anti-diabetes, anti-atherosclerosis, antidepression, healing Alzheimer’s disease (AD), anti-hypertension, toxicology, and untoward reaction are summarized[1]. Geniposide markedly declines the production of IL-8, IL-1β and MCP-1 in OGD-induced brain microvascular endothelial cells, the expression of P2Y14 receptor is significantly down-regulated, the phosphorylation of RAF-1, MEK1/2, ERK1/2 are suppressed[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Geniposide Related Antibodies
    In Vivo

    Geniposide (200 and 400 mg/kg) significantly decreases the blood glucose, insulin and TG levels in diabetic mice in a dose-dependent manner. This compound also decreases the expression of GP and G6Pase at mRNA and immunoreactive protein levels, as well as enzyme activity[3]. Geniposide (20.0, 40.0, or 80 mg/kg) significantly reverses the excessive, alcohol-induced elevation in both serum ALT/AST and hepatic LPO levels. Geniposide upregulates the expression of heme oxygenase-1 (HO-1) to attenuate the cell apoptosis induced by 3-morpholinosydnonimine hydrochloride (SIN-1) in primary cultured hippocampal neurons[4]. Geniposide inhibits photochemistry-induced thromboembolism model in vivo. Geniposide are very effective depressants on NF-κB by interrupting IκB degradation[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    388.37

    Formula

    C17H24O10
    CAS No.
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    O[C@@H]1[C@@H](CO)O[C@@H](O[C@H]2[C@@]3([H])[C@@](CC=C3CO)([H])C(C(OC)=O)=CO2)[C@H](O)[C@H]1O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (257.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 50 mg/mL (128.74 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5749 mL 12.8743 mL 25.7486 mL
    5 mM 0.5150 mL 2.5749 mL 5.1497 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.75 mg/mL (7.08 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.75 mg/mL (7.08 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (257.49 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.55%

    SDS (479 KB)

    COA (259 KB) HNMR (141 KB) RP-HPLC (254 KB) MS (117 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [2]

    The third passages of brain microvascular endothelial cells (BMECs) are used for the experiment. The BMECs are divided into four groups: (1)normal control group: the normal cultured BMECs without treatment; (2)OGD group: the BMECs injured by OGD according to the above method; (3) geniposide group: the OGD-injured BMECs treated with 33.2 μg/mL geniposide for 6 h; (4)PTX group: the OGD-injured BMECs administrated with 100 ng/mL PTX. PTX, known as an inhibitor of Gi-coupled receptor is used to assess the activation of P2Y14 receptor induced by OGD in this experiment[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [3]

    Mice: Type 2 diabetic mice, induced by a high-fat diet and streptozotocin injection, are treated with or without geniposide for 2 weeks. Blood glucose levels are monitored by a glucometer. Insulin concentrations are analyzed by the ELISA method. Total cholesterol (TC) and triglyceride (TG) levels are measured using Labassay kits. Activities of hepatic GP and G6Pase are measured by glucose-6-phosphate dehydrogenase-coupled reaction. Real-time RT-PCR and Western blotting are used to determine the mRNA and protein levels of both enzymes[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.5749 mL 12.8743 mL 25.7486 mL 64.3716 mL
    5 mM 0.5150 mL 2.5749 mL 5.1497 mL 12.8743 mL
    10 mM 0.2575 mL 1.2874 mL 2.5749 mL 6.4372 mL
    15 mM 0.1717 mL 0.8583 mL 1.7166 mL 4.2914 mL
    20 mM 0.1287 mL 0.6437 mL 1.2874 mL 3.2186 mL
    25 mM 0.1030 mL 0.5150 mL 1.0299 mL 2.5749 mL
    30 mM 0.0858 mL 0.4291 mL 0.8583 mL 2.1457 mL
    40 mM 0.0644 mL 0.3219 mL 0.6437 mL 1.6093 mL
    50 mM 0.0515 mL 0.2575 mL 0.5150 mL 1.2874 mL
    60 mM 0.0429 mL 0.2146 mL 0.4291 mL 1.0729 mL
    80 mM 0.0322 mL 0.1609 mL 0.3219 mL 0.8046 mL
    100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.6437 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Geniposide Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Geniposide24512-63-8Amyloid-βInfluenza Virusβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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