Cat. No.: HY-N5083

Saponarin

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1β and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders.

For research use only. We do not sell to patients.

Purity: 99.95%
CAS No.: 20310-89-8
Formula: C₂₇H₃₀O₁₅
Molecular Weight:594.52

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Saponarin Chemical Structure

CAS No.: 20310-89-8

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]^[3]^[4]^[5]^[6]^[7]

IL-1β

COX-2

All NF-κB Isoforms :

All p38 MAPK Isoforms :

All AMPK Isoforms :

All Interleukin Related Isoforms :

All COX Isoforms :

In Vitro

Saponarin (20-60 µM; 4 h) significantly inhibits IL-6 mRNA expression in LPS-induced RAW 264.7 cells via suppression of NF-κB and MAPK (ERK, p38) phosphorylation^[2].
Saponarin (50-100 µM; 24 h) suppresses gluconeogenesis in HepG2 cells by activating AMPK in a calcium-dependent manner, reducing PEPCK and G6Pase gene expression^[3].
Saponarin (2 µmol/mL) inhibits malonaldehyde (MA) formation from Squalene (HY-N1214) by nearly 100% under UV irradiation^[4].
Saponarin (80 µM; 24 h) reduces TNF-α, IL-1β, COX-2 expression and inhibits ERK/p38 phosphorylation in LPS-induced RAW 264.7 cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Saponarin (80 mg/kg; p.o.; 3 weeks) significantly reduces blood glucose levels in Streptozotocin (HY-13753)-induced diabetic normotensive rats and improves liver antioxidant parameters while decreasing MDA levels^[1].
Saponarin (80 mg/kg; p.o.; 3 weeks) shows slight antihypertensive activity in non-diabetic spontaneously hypertensive rats (SHR)^[1].
Saponarin (80 mg/kg; p.o.; for 3 days) protects against Cocaine-induced hepatotoxicity in male Wistar rats by increasing GSH levels and antioxidant enzymes (CAT, SOD, GPx) while reducing MDA formation^[6].
Saponarin (20 mg/kg; p.o.; 5 days) reduces wake time and increases c-Fos expression in the ventrolateral preoptic nucleus (VLPO) in electric footshock-induced sleep-disturbed SD rats^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar Kyoto rats (NTR) and spontaneously hypertensive rats (SHR), male, body weight 180-250 g^[1]
Dosage:

80 mg/kg
Administration:

Oral gavage; for 3 weeks
Result:

Significantly reduced blood glucose levels by 31% in diabetic NTR.
Improved liver antioxidant enzymes (GPx, GR, GST) levels in both diabetic strains (diabetic NTR and diabetic SHR).
Decreased systolic blood pressure by 19% in non-diabetic SHR but had no effect in diabetic SHR.

Chemical Information

CAS No. 20310-89-8
Appearance Solid
Molecular Weight 594.52
Formula C₂₇H₃₀O₁₅
Color White to off-white
SMILES

O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C([C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)C(O)=C13
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (2)

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Journal Impact Factor

Agronomy

2023 Sep 18, 13(9), 2410.
bioRxiv

2026 Jun 26.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (168.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6820 mL

8.4101 mL

16.8203 mL

5 mM

0.3364 mL

1.6820 mL

3.3641 mL

10 mM

0.1682 mL

0.8410 mL

1.6820 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (287 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Simeonova R, et al. Antidiabetic and antioxidant effects of saponarin from Gypsophila trichotoma on streptozotocin-induced diabetic normotensive and hypertensive rats. Phytomedicine. 2016 May 15;23(5):483-90. [Content Brief]

[2]. Seo KH, et al. Saponarin from barley sprouts inhibits NF-κB and MAPK on LPS-induced RAW 264.7 cells. Food Funct. 2014 Nov;5(11):3005-13. [Content Brief]

[3]. Seo WD, et al. Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5237-42. [Content Brief]

[4]. Kamiyama M, et al. Flavonoids with potent antioxidant activity found in young green barley leaves. J Agric Food Chem. 2012 Jun 27;60(25):6260-7. [Content Brief]

[5]. Min SY, et al. Anti-Inflammatory and Anti-Allergic Effects of Saponarin and Its Impact on Signaling Pathways of RAW 264.7, RBL-2H3, and HaCaT Cells. Int J Mol Sci. 2021 Aug 5;22(16):8431. [Content Brief]

[6]. Vitcheva V, et al. Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. Redox Rep. 2011;16(2):56-61. [Content Brief]

[7]. Kim YR, et al. Effect of Hibiscus syriacus Linnaeus extract and its active constituent, saponarin, in animal models of stress-induced sleep disturbances and pentobarbital-induced sleep. Biomed Pharmacother. 2022 Feb;146:112301. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6820 mL	8.4101 mL	16.8203 mL	42.0507 mL
	5 mM	0.3364 mL	1.6820 mL	3.3641 mL	8.4101 mL
	10 mM	0.1682 mL	0.8410 mL	1.6820 mL	4.2051 mL
	15 mM	0.1121 mL	0.5607 mL	1.1214 mL	2.8034 mL
	20 mM	0.0841 mL	0.4205 mL	0.8410 mL	2.1025 mL
	25 mM	0.0673 mL	0.3364 mL	0.6728 mL	1.6820 mL
	30 mM	0.0561 mL	0.2803 mL	0.5607 mL	1.4017 mL
	40 mM	0.0421 mL	0.2103 mL	0.4205 mL	1.0513 mL
	50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.8410 mL
	60 mM	0.0280 mL	0.1402 mL	0.2803 mL	0.7008 mL
	80 mM	0.0210 mL	0.1051 mL	0.2103 mL	0.5256 mL
	100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.4205 mL

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Saponarin

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Publications Citing Use of MedChemExpress (MCE) Saponarin