Squalene  (Synonyms: Super Squalene; trans-Squalene; AddaVax)

Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity^[1][2].

Squalene (12.5, 50 and 200 μM; 24 h) effects on MCF10A epithelial cells in a dose-dependent manner: (a) it decreases intracellular ROS level, (b) it prevents H2O2-induced oxidative injury, and (c) it protects against oxidative DNA damage^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Squalene (0.25-1 g/kg; fed chow; diets for 11 weeks) promotes changes in HDL- cholesterol and paraoxonase 1 and decreases reactive oxygen species in lipoproteins and plasma malondialdehyde levels^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

410.72

C₃₀H₅₀

111-02-4

Liquid (Density: 0.858 g/cm³)

Colorless to light yellow

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C

Room temperature in continental US; may vary elsewhere.

• [1]. Muzalevskaya EN, et al. SQUALENE: PHYSIOLOGICAL AND PHARMACOLOGICAL PROPERTIES. Eksp Klin Farmakol. 2015;78(6):30-6.  [Content Brief]

  [2]. Fernando Warleta, et al. Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells. Food Chem Toxicol. 2010 Apr;48(4):1092-100.  [Content Brief]

  [3]. Clara Gabás-Rivera, et al. Dietary squalene increases high density lipoprotein-cholesterol and paraoxonase 1 and decreases oxidative stress in mice. PLoS One. 2014 Aug 12;9(8):e104224.  [Content Brief]