(E/Z)-Squalene
(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner.
For research use only. We do not sell to patients.
- CAS No.: 7683-64-9
- Formula: C30H50
- Molecular Weight:410.72
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
>50 μM
Compound: 20
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTS reduction assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS reduction assay
|
[PMID: 20704331] |
| NCI-H460 | IC50 |
>50 μM
Compound: 20
|
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTS reduction assay
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTS reduction assay
|
[PMID: 20704331] |
| Neutrophil | IC50 |
>30 μM
Compound: 8
|
Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge
Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge
|
[PMID: 19203247] |
| SF-268 | IC50 |
>50 μM
Compound: 20
|
Cytotoxicity against human SF268 cells after 72 hrs by MTS reduction assay
Cytotoxicity against human SF268 cells after 72 hrs by MTS reduction assay
|
[PMID: 20704331] |
(E/Z)-Squalene (0-50 μM) reduces intracellular ROS levels in human mammary epithelial cells (MCF10A), prevents H2O2-induced oxidative damage, and protects cells from DNA oxidative damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 7683-64-9
-
Molecular Weight 410.72
-
Formula C30H50
-
SMILES
C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C
-
Synonyms
(E/Z)-Super Squalene; (E/Z)-AddaVax
-
Structure Classification
-
Initial Source
Human Blood, Feces, Sweat
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)