1. Neuronal Signaling
  2. Amyloid-β
  3. Notoginsenoside R1

Notoginsenoside R1 (Synonyms: Sanchinoside R1; Sanqi glucoside R1)

Cat. No.: HY-N0615 Purity: >97.0%
Handling Instructions

Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported have some neuronal protective, antihypertensive effects.

For research use only. We do not sell to patients.

Notoginsenoside R1 Chemical Structure

Notoginsenoside R1 Chemical Structure

CAS No. : 80418-24-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 111 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects. IC50 value: Target: In vitro: In vivo: Notoginsenoside R1 significantly reduce blood pressure in spontaneously hypertensive rats and induce nitric oxide generation through increasing the phosphorylation of iNOS. Notoginsenoside R1 reduces the caudal blood pressure of spontaneously hypertensive rats through induction of iNOS regulated by long non-coding RNA AK094457 [1]. The mice with notoginsenoside R1 treatment showed significant amelioration in the cognitive function and increased choline acetyl transferase expression, as compared to the vehicle treated mice. Notoginsenoside R1 treatment inhibited Aβ accumulation and increased insulin degrading enzyme expression in both APP/PS1 mice and N2a-APP695sw cells [2]. In Notoginsenoside R1 treated rats, expression of TGF-β1and Smad3 at each time point was down-regulated, with statistical significance(P0.05) compared with that in the NDMA group [3].

Molecular Weight

933.13

Formula

C₄₇H₈₀O₁₈

CAS No.

80418-24-2

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (107.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0717 mL 5.3583 mL 10.7166 mL
5 mM 0.2143 mL 1.0717 mL 2.1433 mL
10 mM 0.1072 mL 0.5358 mL 1.0717 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (3.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (3.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (3.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Notoginsenoside R1
Cat. No.:
HY-N0615
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