1. Neuronal Signaling
    Apoptosis
  2. Amyloid-β
    Apoptosis
  3. Notoginsenoside R1

Notoginsenoside R1 (Synonyms: Sanchinoside R1; Sanqi glucoside R1)

Cat. No.: HY-N0615 Purity: ≥98.0%
Handling Instructions

Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells.

For research use only. We do not sell to patients.

Notoginsenoside R1 Chemical Structure

Notoginsenoside R1 Chemical Structure

CAS No. : 80418-24-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 111 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 111 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Notoginsenoside R1

    Notoginsenoside R1 purchased from MCE. Usage Cited in: Front Cell Neurosci. 2020 Sep 4;14:280.

    Effect of Notoginsenoside R1 (R1; 5 μM) on the expression, location, and cleavage status of sodium channel proteins after Aβ1-42 treatment.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells[1][2][3].

    In Vitro

    Notoginsenoside R1 (2.5-80 μM; 24 h) inhibits the hypoxia-reoxygenation (H/R)-induced cell death, intracellular ROS accumulation, and mitochondrial membrane depolarization in H9c2 cardiomyocytes[1].
    Notoginsenoside R1 (5-20 μM; 24 h) inhibits the H/R-induced H9c2 cardiomyocytes apoptosis in a concentration-dependent manner[1].
    Notoginsenoside R1 (1-100 μM; 24 h) dose-dependently protects PC12 cells and primary neurons from Aβ-induced cell death and apoptosis[2].
    Notoginsenoside R1 (10 μM; 24 h) inhibits Aβ25-35-induced ROS production, mitochondrial damage and MAPK activation in PC12 cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Notoginsenoside R1 (5 mg/kg/h; infused via the right jugular vein) increases red blood cell velocity, reduces the number of adherent leukocytes and inhibits mast cell degranulation and cytokine elevation in rats[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Sprague-Dawley (SD) rats (200-250 g)[3]
    Dosage: 5 mg/kg/h
    Administration: Infused 20 min before LPS infusion via the right jugular vein
    Result: Ameliorated the LPS-induced reduction in the mesenteric venular shear rate to some extent.
    Attenuated the LPS-induced adhesion of leukocytes to the venular wall.
    Inhibited mast cell degranulation and cytokine elevation.
    Molecular Weight

    933.13

    Formula

    C₄₇H₈₀O₁₈

    CAS No.
    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (107.17 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.0717 mL 5.3583 mL 10.7166 mL
    5 mM 0.2143 mL 1.0717 mL 2.1433 mL
    10 mM 0.1072 mL 0.5358 mL 1.0717 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: ≥98.0%

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    Keywords:

    Notoginsenoside R1Sanchinoside R1 Sanqi glucoside R1Notoginsenoside R 1Notoginsenoside R-1Sanchinoside R 1Sanchinoside R-1Sanqi glucoside R1Sanqi glucoside R 1Sanqi glucoside R-1Amyloid-βApoptosisβ-amyloid peptideAbetasaponinanti-oxidationanti-inflammatoryanti-angiogenicanti-apoptosis,cardioprotectionI/RneuroprotectionInhibitorinhibitorinhibit

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    Product Name:
    Notoginsenoside R1
    Cat. No.:
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