80418-24-2
80418-24-2
Chemical Structure
Notoginsenoside R1
Synonym(s): Sanchinoside R1; Sanqi glucoside R1
- CAS No.: 80418-24-2
- Formula:C47H80O18
- Molecular Weight:933.13
IUPAC Name: (2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-6-(((2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-3,12-dihydroxy-4,4,8,10,14-pentamethylhexade
InChIKey: LLPWNQMSUYAGQI-OOSPGMBYSA-N
SMILES: C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(C[C@H](O[C@@](O[C@H](CO)[C@@H](O)[C@@H]4O)([H])[C@@H]4O[C@@](OC[C@@H](O)[C@@H]5O)([H])[C@@H]5O)[C@@]2([H])C3(C)C)[C@]6([C@@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO)([H])CC6)C
Biological Activity: Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Notoginsenoside R1 | 99.68% | Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells. | ||||||||||||||||||||
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Notoginsenoside R1 (Standard) | ≥98% | Notoginsenoside R1 (Standard) is the analytical standard of Notoginsenoside R1. This product is intended for research and analytical applications. Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells. | ||||||||||||||||||||
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Ginsenoside Rd | 99.88% | Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively. | ||||||||||||||||||||
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Ginsenoside Re (Standard) | ≥98% | Ginsenoside Re (Standard) is the analytical standard of Ginsenoside Re. This product is intended for research and analytical applications. Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB. | ||||||||||||||||||||
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Ginsenoside Rg1 | 99.88% | Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation. | ||||||||||||||||||||
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Ginsenoside Rf | 99.48% | Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel. | ||||||||||||||||||||
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Notoginsenoside R2 (Standard) | ≥98% | Notoginsenoside R2 (Standard) is the analytical standard of Notoginsenoside R2. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Notoginsenoside R3 | 98.15% | Notoginsenoside R3 is an active principle components of P. notoginseng. Notoginsenoside R3 act as a signaling molecule that is associated with various physiological effects. P. notoginseng and its components are used as traditional Chinese medicine for cardiovascular disease. | ||||||||||||||||||||
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Pseudoginsenoside-RT3 | Pseudoginsenoside-RT3 is a natural product that can be found in Panax notoginseng?(Burkill) F. H. Chen ex C. H. Chow. | |||||||||||||||||||||
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Gypenoside XCI | Gypenoside XCI is a glycoside found in Gynostemma pentaphyllum. | |||||||||||||||||||||
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Vinaginsenoside R4 | 99.86% | Vinaginsenoside R4, isolated from the leaves of hydroponic Panax ginseng. It has an inhibitory effect on melanin biosynthesis without any cytotoxic effects on the melan-a cells, and enhances the depigmentation on the zebrafish. | ||||||||||||||||||||
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20-Gluco-ginsenoside-Rf | 20-Gluco-ginsenoside-Rf (compound 4) is a bisdesmosidic saponin that can be obtained from the roots of Panax ginseng. | |||||||||||||||||||||
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References
- [1]. Yu Y, et, al. Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways. Sci Rep. 2016 Feb 18;6:21730. [Content Brief]
- [2]. Ma B, et, al. Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation. Int Immunopharmacol. 2014 Sep;22(1):151-9. [Content Brief]
- [3]. Sun K, et, al. Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Life Sci. 2007 Jul 19;81(6):509-18. [Content Brief]
