6-O-Methylinosine

Cat. No.: HY-152696 Purity: 99.17%: Data Sheet
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6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

For research use only. We do not sell to patients.

6-O-Methylinosine Chemical Structure

CAS No. : 5746-29-2

Size	Price	Stock
250 mg		Ask For Quote & Lead Time
1 g		Ask For Quote & Lead Time
5 g		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC₅₀	> 300 μM Compound: 3	Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay	[PMID: 17336519]

Molecular Weight

282.25

Formula

C₁₁H₁₄N₄O₅

CAS No.

5746-29-2

Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(OC)=NC=N3)O[C@@H]1CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (442.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5430 mL	17.7148 mL	35.4296 mL
5 mM	0.7086 mL	3.5430 mL	7.0859 mL
10 mM	0.3543 mL	1.7715 mL	3.5430 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.17%

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Data Sheet (275 KB) SDS (393 KB)

COA (253 KB) HNMR (255 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. [Content Brief]

[2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5430 mL	17.7148 mL	35.4296 mL	88.5740 mL
	5 mM	0.7086 mL	3.5430 mL	7.0859 mL	17.7148 mL
	10 mM	0.3543 mL	1.7715 mL	3.5430 mL	8.8574 mL
	15 mM	0.2362 mL	1.1810 mL	2.3620 mL	5.9049 mL
	20 mM	0.1771 mL	0.8857 mL	1.7715 mL	4.4287 mL
	25 mM	0.1417 mL	0.7086 mL	1.4172 mL	3.5430 mL
	30 mM	0.1181 mL	0.5905 mL	1.1810 mL	2.9525 mL
	40 mM	0.0886 mL	0.4429 mL	0.8857 mL	2.2143 mL
	50 mM	0.0709 mL	0.3543 mL	0.7086 mL	1.7715 mL
	60 mM	0.0590 mL	0.2952 mL	0.5905 mL	1.4762 mL
	80 mM	0.0443 mL	0.2214 mL	0.4429 mL	1.1072 mL
	100 mM	0.0354 mL	0.1771 mL	0.3543 mL	0.8857 mL