6-O-Methylinosine
6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
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- Pureza : 99.17%
- No. CAS: 5746-29-2
- Fòrmula: C11H14N4O5
- Peso molecular:282.25
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
>300 μM
Compound: 3
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Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay
Antiviral activity against SARS-CoV Frankfurt1 in Vero E6 cells by plaque reduction assay
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[PMID: 17336519] |
Chemical Information
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No. CAS 5746-29-2
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Appearance Solid
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Peso molecular 282.25
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Fòrmula C11H14N4O5
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Color White to light yellow
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SMILES
O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(OC)=NC=N3)O[C@@H]1CO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (442.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. [Content Brief]
[2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5430 mL | 17.7148 mL | 35.4296 mL | 88.5740 mL |
| 5 mM | 0.7086 mL | 3.5430 mL | 7.0859 mL | 17.7148 mL | |
| 10 mM | 0.3543 mL | 1.7715 mL | 3.5430 mL | 8.8574 mL | |
| 15 mM | 0.2362 mL | 1.1810 mL | 2.3620 mL | 5.9049 mL | |
| 20 mM | 0.1771 mL | 0.8857 mL | 1.7715 mL | 4.4287 mL | |
| 25 mM | 0.1417 mL | 0.7086 mL | 1.4172 mL | 3.5430 mL | |
| 30 mM | 0.1181 mL | 0.5905 mL | 1.1810 mL | 2.9525 mL | |
| 40 mM | 0.0886 mL | 0.4429 mL | 0.8857 mL | 2.2143 mL | |
| 50 mM | 0.0709 mL | 0.3543 mL | 0.7086 mL | 1.7715 mL | |
| 60 mM | 0.0590 mL | 0.2952 mL | 0.5905 mL | 1.4762 mL | |
| 80 mM | 0.0443 mL | 0.2214 mL | 0.4429 mL | 1.1072 mL | |
| 100 mM | 0.0354 mL | 0.1771 mL | 0.3543 mL | 0.8857 mL |
6-O-Methylinosine Related Classifications
HY-152696 Related Classifications
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