2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 3-Methylxanthine

3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.

For research use only. We do not sell to patients.

3-Methylxanthine Chemical Structure

3-Methylxanthine Chemical Structure

CAS No. : 1076-22-8

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of 3-Methylxanthine:

3-Methylxanthine Related Antibodies

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Description

3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.

IC50 & Target[1]

GMP

920 μM (IC50)

Human Endogenous Metabolite

 

Molecular Weight

166.14

Formula

C6H6N4O2
CAS No.
Appearance

Solid

SMILES

O=C1N(C)C2=C(N=CN2)C(N1)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M NaOH : 50 mg/mL (300.95 mM; ultrasonic and adjust pH to 11 with 1M NaOH)

DMSO : 2.61 mg/mL (15.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0190 mL 30.0951 mL 60.1902 mL
5 mM 1.2038 mL 6.0190 mL 12.0380 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.62%

COA (252 KB) LCMS (114 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 1M NaOH 1 mM 6.0190 mL 30.0951 mL 60.1902 mL 150.4755 mL
5 mM 1.2038 mL 6.0190 mL 12.0380 mL 30.0951 mL
10 mM 0.6019 mL 3.0095 mL 6.0190 mL 15.0476 mL
15 mM 0.4013 mL 2.0063 mL 4.0127 mL 10.0317 mL
1M NaOH 20 mM 0.3010 mL 1.5048 mL 3.0095 mL 7.5238 mL
25 mM 0.2408 mL 1.2038 mL 2.4076 mL 6.0190 mL
30 mM 0.2006 mL 1.0032 mL 2.0063 mL 5.0159 mL
40 mM 0.1505 mL 0.7524 mL 1.5048 mL 3.7619 mL
50 mM 0.1204 mL 0.6019 mL 1.2038 mL 3.0095 mL
60 mM 0.1003 mL 0.5016 mL 1.0032 mL 2.5079 mL
80 mM 0.0752 mL 0.3762 mL 0.7524 mL 1.8809 mL
100 mM 0.0602 mL 0.3010 mL 0.6019 mL 1.5048 mL
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3-Methylxanthine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Methylxanthine1076-22-8Endogenous MetaboliteInhibitorinhibitorinhibit

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