3-Methylxanthine
Based on 1 Customer Validation
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 1076-22-8
- Formula: C6H6N4O2
- Molecular Weight:166.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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GMP 920 μM (IC50) |
Chemical Information
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CAS No. 1076-22-8
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Appearance Solid
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Molecular Weight 166.14
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Formula C6H6N4O2
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Color White to khaki
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SMILES
O=C1N(C)C2=C(N=CN2)C(N1)=O
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
1M NaOH : 50 mg/mL (300.95 mM; ultrasonic and adjust pH to 11 with 1M NaOH)
DMSO : 2 mg/mL (12.04 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Tanaka H, et al. Inhibition of cyclic GMP phosphodiesterase by xanthine derivatives relaxes guinea-pig trachealis smooth muscle. Clin Exp Pharmacol Physiol. 1991 Mar;18(3):163-8. [Content Brief]
[2]. Yamamoto K, et al. Neurotoxic convulsions induced by theophylline and its metabolites in mice. Biol Pharm Bull. 1996 Jun;19(6):869-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1M NaOH | 1 mM | 6.0190 mL | 30.0951 mL | 60.1902 mL | 150.4755 mL |
| 5 mM | 1.2038 mL | 6.0190 mL | 12.0380 mL | 30.0951 mL | |
| 10 mM | 0.6019 mL | 3.0095 mL | 6.0190 mL | 15.0476 mL | |
| 1M NaOH | 15 mM | 0.4013 mL | 2.0063 mL | 4.0127 mL | 10.0317 mL |
| 20 mM | 0.3010 mL | 1.5048 mL | 3.0095 mL | 7.5238 mL | |
| 25 mM | 0.2408 mL | 1.2038 mL | 2.4076 mL | 6.0190 mL | |
| 30 mM | 0.2006 mL | 1.0032 mL | 2.0063 mL | 5.0159 mL | |
| 40 mM | 0.1505 mL | 0.7524 mL | 1.5048 mL | 3.7619 mL | |
| 50 mM | 0.1204 mL | 0.6019 mL | 1.2038 mL | 3.0095 mL | |
| 60 mM | 0.1003 mL | 0.5016 mL | 1.0032 mL | 2.5079 mL | |
| 80 mM | 0.0752 mL | 0.3762 mL | 0.7524 mL | 1.8809 mL | |
| 100 mM | 0.0602 mL | 0.3010 mL | 0.6019 mL | 1.5048 mL |
3-Methylxanthine Related Classifications
HY-50723 Related Classifications
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