8-Azaadenine
Based on 1 Customer Validation
8-Azaadenine is an inhibitor of Xanthine Oxidase with an IC50 of 0.54 μM and a Ki of 0.66 μM. 8-Azaadenine can be produced via the metabolism of 8-Azaadenosine (HY-115686) and incorporated into polynucleotide chains together with 8-Azaguanine (HY-B1468) to affect purine metabolism. 8-Azaadenine can be used in the study of cancer.
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- Pureté : 99.85%
- CAS No.: 1123-54-2
- Formule: C4H4N6
- Masse moléculaire:136.12
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-B0152
AdenineNucleobase -
HY-B0219
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HY-B0219R
Allopurinol (Standard)Xanthine Oxidase Inhibitor -
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PurpurogallinXanthine Oxidase Inhibitor -
HY-B0219A
Allopurinol sodiumXanthine Oxidase Inhibitor -
HY-N1547
PrudomestinXanthine Oxidase Inhibitor -
HY-112103
6-(γ,γ-Dimethylallylamino)purineNatural Product -
HY-B0152R
Adenine (Standard)Nucleobase -
HY-77336
6-Chloro-7-iodo-7-deazapurineBiochemical Reagent -
HY-12136R
Purpurogallin (Standard)Xanthine Oxidase Inhibitor -
HY-N1547R
Prudomestin (Standard)Xanthine Oxidase Inhibitor -
HY-N7150
Tricetin 3',4',5'-trimethyl etherXanthine Oxidase Inhibitor
Activité biologique
Description
In Vitro
Chemical Information
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CAS No. 1123-54-2
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Appearance Solid
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Masse moléculaire 136.12
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Formule C4H4N6
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Color White to light yellow
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SMILES
NC1=C(N=NN2)C2=NC=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
In Vitro:
DMSO : 25 mg/mL (183.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (18.37 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Sheu SY, et al. Inhibition of xanthine oxidase by synthetic cytokinin analogues. Anticancer Res. 1997 Mar-Apr;17(2A):1043-9. [Content Brief]
[2]. Holý A, et al Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity. J Med Chem. 1996 Sep 27;39(20):4073-88. [Content Brief]
[3]. Bennett LL Jr, et al. Metabolism and metabolic effects of 8-azainosine and 8-azaadenosine. Cancer Res. 1976 Nov;36(11 Pt 1):3917-23. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 7.3465 mL | 36.7323 mL | 73.4646 mL | 183.6615 mL |
| 5 mM | 1.4693 mL | 7.3465 mL | 14.6929 mL | 36.7323 mL | |
| 10 mM | 0.7346 mL | 3.6732 mL | 7.3465 mL | 18.3661 mL | |
| 15 mM | 0.4898 mL | 2.4488 mL | 4.8976 mL | 12.2441 mL | |
| 20 mM | 0.3673 mL | 1.8366 mL | 3.6732 mL | 9.1831 mL | |
| 25 mM | 0.2939 mL | 1.4693 mL | 2.9386 mL | 7.3465 mL | |
| 30 mM | 0.2449 mL | 1.2244 mL | 2.4488 mL | 6.1220 mL | |
| 40 mM | 0.1837 mL | 0.9183 mL | 1.8366 mL | 4.5915 mL | |
| 50 mM | 0.1469 mL | 0.7346 mL | 1.4693 mL | 3.6732 mL | |
| 60 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0610 mL | |
| 80 mM | 0.0918 mL | 0.4592 mL | 0.9183 mL | 2.2958 mL | |
| 100 mM | 0.0735 mL | 0.3673 mL | 0.7346 mL | 1.8366 mL |
8-Azaadenine Related Classifications
HY-W008550 Related Classifications
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