1. Metabolic Enzyme/Protease
  2. Adenosine Deaminase
  3. 8-Azaadenosine

8-Azaadenosine 

Cat. No.: HY-115686 Purity: 99.39%
Handling Instructions

8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells.

For research use only. We do not sell to patients.

8-Azaadenosine Chemical Structure

8-Azaadenosine Chemical Structure

CAS No. : 10299-44-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 138 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 138 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 125 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells[1][2].

In Vitro

8-Azaadenosine targets ADAR (adenosine deaminases acting on double-stranded RNA) activity only and does not affect ADAR1 mRNA levels[1][2].
8-Azaadenosine (10-25 nM) restores let-7 miRNA biogenesis commensurate with a reduction in ADAR1 expression, RNA editing activity and LIN28B expression in JAK2/BCR-ABL1 transduced progenitors after two weeks in stromal co-culture[1].
8-Azaadenosine (10, 100 nM) shows no effect on BCR-ABL and JAK2 signaling, as demonstrated by qRT-PCR analysis and p-CRKL and p-STAT5a Western blot analysis[1].
8-Azaadenosine (0.1, 0.5, 1, 2 µM; 5 days) decreases cell viability/proliferation in a dose-dependent manner in TPC1 and Cal62 cells[2].
8-Azaadenosine (1, 2 µM; 16 hours) impedes invasion and migration of TPC1 and Cal62 cells[2].
8-Azaadenosine (1, 2 µM) inhibits the editing activity in TPC1 and Cal62 cells. By contrast, ADAR1 mRNA levels remains stable in both cells lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

268.23

Formula

C₉H₁₂N₆O₄

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (932.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7281 mL 18.6407 mL 37.2814 mL
5 mM 0.7456 mL 3.7281 mL 7.4563 mL
10 mM 0.3728 mL 1.8641 mL 3.7281 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.75 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.75 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.94%

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Keywords:

8-AzaadenosineAdenosine DeaminaseADAR1A-to-IeditingRNAproliferationinvasionmigrationthyroidTPC1Cal62LIN28BInhibitorinhibitorinhibit

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Product Name:
8-Azaadenosine
Cat. No.:
HY-115686
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