Signaling Pathway

Adenosine Deaminase

Adenosine Deaminase

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Adenosine deaminase (ADA) is an enzyme involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in humans is the development and maintenance of the immune system. ADA is considered one of the key enzymes of purine metabolism. ADA in humans is involved in the development and maintenance of the immune system. However, ADA association has also been observed with epithelial cell differentiation, neurotransmission, and gestation maintenance. It has also been proposed that ADA, in addition to adenosine breakdown, stimulates release of excitatory amino acids and is necessary to the coupling of A1 adenosine receptors and heterotrimeric G proteins.

Adenosine Deaminase Inhibitors & Modulators (2)

Product Name Catalog No. Brief Description
Cladribine

HY-13599

Cladribine is an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiple sclerosis.

Pentostatin

HY-A0006

Pentostatin(Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM).