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Coformycin

Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity.

For research use only. We do not sell to patients.

CAS No.: 11033-22-0
Formula: C₁₁H₁₆N₄O₅
Molecular Weight:284.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Coformycin Chemical Structure

CAS No.: 11033-22-0

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Sample (0.1mg)

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(In Japan)

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity^[1]^[2].

All Antibiotic Isoforms :

In Vivo

Coformycin (0.2 mg/kg, ip daily) inhibits adenosine deaminase activity for various tissues, including brain, heart, kidney, liver, etc^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss-Webster mice^[2].
Dosage:

0.2 mg/kg.
Administration:

IP daily.
Result:

Inhibited adenosine deaminase activity for various tissues.

Chemical Information

CAS No. 11033-22-0
Molecular Weight 284.27
Formula C₁₁H₁₆N₄O₅
SMILES

O[C@H]1C2=C(NC=NC1)N(C=N2)[C@H]3[C@H](O)[C@H](O)[C@H](O3)CO
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Nocardia interforma and Streptomyces kaniharaensis SF-557
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Coformycin.

[2]. Lukey T, et al. S-adenosylhomocysteine hydrolase activity, deoxyadenosine triphosphate accumulation, and competence of thymocyte and spleen leucocyte response to mitogens in coformycin-treated mice. Biochem Pharmacol. 1983 Apr 15;32(8):1399-406. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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