EHNA hydrochloride (Standard)
EHNA hydrochloride (Standard) is the analytical standard of EHNA hydrochloride (HY-103160A). This product is intended for research and analytical applications. EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects.
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- CAS. Nr.: 58337-38-5
- Formel: C14H24ClN5O
- Molecular Weight:313.83
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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HY-103160A
EHNA hydrochloridePDE2 Inhibitor -
HY-A0006
PentostatinAntibiotic -
HY-103159
1-DeazaadenosineADA Inhibitor -
HY-12318
IBMXPDE Inhibitor -
HY-N7368
HibifolinADA Inhibitor -
HY-101312
CilostamidePDE3 Inhibitor -
HY-103673
AMPD2 inhibitor 1AMPD2 Inhibitor -
HY-115686
8-AzaadenosineADAR1 Inhibitor -
HY-12318R
IBMX (Standard)PDE Inhibitor -
HY-14917
CapadenosonAdenosine Receptor Agonist -
HY-12318G
IBMX (GMP)PDE Inhibitor -
HY-A0006R
Pentostatin (Standard)Antibiotic
Product Information
Information
Anwendung
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS. Nr. 58337-38-5
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Molecular Weight 313.83
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Formel C14H24ClN5O
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SMILES
CCCCCC[C@@](N1C2=C(C(N)=NC=N2)N=C1)([H])[C@H](O)C.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Podzuweit T, et al. Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine.Cell Signal. 1995 Sep;7(7):733-8. [Content Brief]
[2]. Michie AM, et al. Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.Cell Signal. 1996 Feb;8(2):97-110. [Content Brief]
[3]. Blázquez-Bermejo C, et al. Increased dNTP pools rescue mtDNA depletion in human POLG-deficient fibroblasts. FASEB J. 2019 Jun;33(6):7168-7179. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
EHNA hydrochloride (Standard) Related Classifications
HY-103160AR Related Classifications
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